1-甲基-1H-吡咯并[2,3-b]吡啶-3-甲醛合成路线 （共 8 条）
反应条件
trichlorophosphate a) 0 deg C, 1.5 h, b) 60 deg C, 0.5 h;
参考文献
ASTRAZENECA AB
Patent: WO2005/66132 A1, 2005 ;
Location in patent: Page/Page column 66 ;
WO 2005/066132 A1
反应条件
sodium hydrogencarbonate; trichlorophosphate in ethyl acetate; N,N-dimethyl-formamide
参考文献
DAIICHI PHARMACEUTICAL CO., LTD.
Patent: EP1346982 A1, 2003 ;
反应条件
1: 1H-Pyrrolo[2,3-b]pyridine-3-carbaldehyde With sodium hydride in tetrahydrofuran T=0 - 20°C; 2: methyl iodide in tetrahydrofuran 2 h;
参考文献
Chavan, Neelam L.; Nayak, Sandip K.; Kusurkar, Radhika S.
Tetrahedron, 2010 , vol. 66, # 10 p. 1827 - 1831
反应条件
1,4-diaza-bicyclo[2.2.2]octane in N,N-dimethyl-formamide T=90 - 92°C; 23 h;
参考文献
Laurila, Michael L.; Magnus, Nicholas A.; Staszak, Michael A.
Organic Process Research and Development, 2009 , vol. 13, # 6 p. 1199 - 1201
反应条件
oxygen; copper dichloride in water; dimethyl sulfoxide T=120°C; 4 h;
参考文献
Chen, Jianbin; Liu, Bin; Liu, Dongfang; Liu, Shan; Cheng, Jiang
Advanced Synthesis and Catalysis, 2012 , vol. 354, # 13 p. 2438 - 2442
反应条件
ammonium acetate; water T=150°C; 48 h; Inert atmosphereSealed tube;
参考文献
Fei, Haiyang; Yu, Jintao; Jiang, Yan; Guo, Huan; Cheng, Jiang
Organic and Biomolecular Chemistry, 2013 , vol. 11, # 41 p. 7092 - 7095
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C / Inert atmosphere 1.2: 0 - 20 °C / Inert atmosphere 2.1: trichlorophosphate / 0.25 h / 20 °C / Inert atmosphere 2.2: 0 - 40 °C / Inert atmosphere View Scheme
参考文献
Heteroatom Chemistry, , vol. 22, # 2 p. 148 - 157
反应条件
potassium permanganate in acetone 1 h; Ambient temperature;
参考文献
Kato; Ito; Nishino; Yamakuni; Takasugi
Chemical and pharmaceutical bulletin, 1995 , vol. 43, # 8 p. 1351 - 1357
