1-甲基-1H-吡咯并[2,3-B]吡啶-3-羧酸合成路线 （共 3 条）
反应条件
potassium permanganate in acetone 1 h; Ambient temperature;
参考文献
Kato; Ito; Nishino; Yamakuni; Takasugi
Chemical and pharmaceutical bulletin, 1995 , vol. 43, # 8 p. 1351 - 1357
反应条件
1: 74 percent / POCl3 / a) 0 deg C, 1.5 h, b) 60 deg C, 0.5 h 2: 58 percent / aq. KMnO4 / acetone / 1 h / Ambient temperature View Scheme
参考文献
Kato; Ito; Nishino; Yamakuni; Takasugi
Chemical and pharmaceutical bulletin, 1995 , vol. 43, # 8 p. 1351 - 1357
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.67 h / 0 °C 1.2: 3 h / 20 °C 2.1: hydrogenchloride; water / 20 h / 70 °C 3.1: water; carbon / 0.5 h / 70 °C View Scheme
参考文献
Pierce, Larry T.; Cahill, Michael M.; Winfield, Hannah J.; McCarthy, Florence O.
European Journal of Medicinal Chemistry, 2012 , vol. 56, p. 292 - 300
