(S)-4-硝基苯基丙氨酸甲酯盐酸盐合成路线 (共 12 条)
反应条件
thionyl chloride Ambient temperature;
参考文献
Glen, Robert C.; Martin, Graeme R.; Hill, Alan P.; Hyde, Richard M.; Woollard, Patrick M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3566 - 3580
反应条件
thionyl chloride in methanol
参考文献
Moroder, Luis; Stefan, Sperl; Sturzebecher, Jorg
Patent: US2003/21773 A1, 2003 ;
US 20030021773 A1
反应条件
thionyl chloride T=20°C; 3.5 h; Cooling with dry-ice-acetonitrile;
参考文献
EP1477482 A1, ;
Page 64 ;
反应条件
thionyl chloride in methanol
反应条件
1: 53 percent / conc. H2SO4, conc. HNO3 / 0.5 h / Ambient temperature 2: 76 percent / SOCl2 / 4 h / -10 - 40 °C View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 40, # 15 p. 2347 - 2362
反应条件
1: sodium carbonate 2: 10 palladium on activated charcoal; hydrogen View Scheme
参考文献
Goldberg, Jacob M.; Speight, Lee C.; Fegley, Mark W.; Petersson, E. James
Journal of the American Chemical Society, 2012 , vol. 134, # 14 p. 6088 - 6091
反应条件
1: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating 2: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C View Scheme
参考文献
Tian, Xiang-Yin; Han, Jian-Wei; Zhao, Qiong; Wong, Henry N. C.
Organic and Biomolecular Chemistry, 2014 , vol. 12, # 22 p. 3686 - 3700
反应条件
1: 46 percent / sodium borohydride / ethanol; H2O / 2.5 h / Heating 2: 36 percent / aq. KOH / toluene / 1 h / 0 °C 3: 97 percent / H2, aq. 2 N HCl / 10percent Pd/C / ethanol; ethyl acetate 4: 1.) aq. HCl, NaNO2, 2.) SnCl2 / 1.) from -5 deg C to 0 deg C, 30 min, 2.) RT, 3 h 5: 0.21 g / ethanol; H2O / 2 h / Heating View Scheme
参考文献
Glen, Robert C.; Martin, Graeme R.; Hill, Alan P.; Hyde, Richard M.; Woollard, Patrick M.; et al.
Journal of Medicinal Chemistry, 1995 , vol. 38, # 18 p. 3566 - 3580
反应条件
1: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating 2: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C 3: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature View Scheme
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362
反应条件
1: 65 percent / NaBH4 / ethanol; H2O / 4 h / Heating
2: 75 percent / 0.2M aq. KOH / toluene / 2 h / 0 - 20 °C
3: 79 percent / H2, aq. HCl / 10percent Pd/C / ethanol / 760 Torr / Ambient temperature
4: conc. aq. HCl, NaNO2 / 0.5 h / 0 °C
5: 1.) aq. KOH, 3.) aq. HCl
6: polyphosphoric ester / CHCl3 / 8 h / Heating
View Scheme
参考文献
Moloney, Gerard P.; Robertson, Alan D.; Martin, Graeme R.; MacLennan, Steven; Mathews, Neil; Dodsworth, Susan; Sang, Pang Yih; Knight, Cameron; Glen, Robert
Journal of Medicinal Chemistry, 1997 , vol. 40, # 15 p. 2347 - 2362