(S)-(+)-扁桃酸合成路线 (共 229 条)
反应条件
1: 93 percent / 98 percent H2SO4 / 4 h / Heating 2: Mg / tetrahydrofuran / 16 h / Heating View Scheme
参考文献
Millar, A.; Mulder, L. W.; Mennen, K. E.; Palmer, C. W.
Organic Preparations and Procedures International, 1991 , vol. 23, # 2 p. 173 - 180
反应条件
1: PCl5 / 160 °C 2: water View Scheme
参考文献
Walden
Chemische Berichte, 1895 , vol. 28, p. 1295,1296
Zhurnal Russkago Fiziko-Khimicheskago Obshchestva, 1898 , vol. 30, p. 535,538
反应条件
1-amino-1-phenylethane in hexan-1-ol T=130°C; Racemization; Kinetics; Further Variations:ReagentsSolventsTemperatures;
参考文献
Hollemann
Recueil des Travaux Chimiques des Pays-Bas, 1898 , vol. 17, p. 324
反应条件
1: borane 2: 31 percent / pyridine / 24 h / 0 - 5 °C 3: NaOMe / methanol View Scheme
参考文献
Robinson, Philip L.; Barry, Carey N.; Bass, S. Woody; Jarvis, Susan E.; Evans, Slayton A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5396 - 5398
反应条件
phosphorus pentachloride T=160°C; chloride of/the/ dextrorotatory phenylchloroacetic acid;
参考文献
Marzorati, Liliana; Fejfar, Jose L.; Tormena, Claudio F.; Vitta, Claudio Di
Tetrahedron Asymmetry, 2012 , vol. 23, # 10 p. 748 - 753
反应条件
1: 70 percent / borane 2: diethoxytriphenylphosphorane / CH2Cl2 / Heating; var. cyclodehydr. reag., var. solv., var. temp.; regioselectivity View Scheme
参考文献
Robinson, Philip L.; Barry, Carey N.; Bass, S. Woody; Jarvis, Susan E.; Evans, Slayton A.
Journal of Organic Chemistry, 1983 , vol. 48, # 26 p. 5396 - 5398
反应条件
lithium aluminium tetrahydride in tetrahydrofuran 8 h; Heating;
参考文献
Pandey, Ganesh; Gaikwad, Amrut L.; Gadre, Smita R.
Tetrahedron Letters, 2006 , vol. 47, # 5 p. 701 - 703
反应条件
sodium hydroxide in water T=45°C; 3 h;
参考文献
Journal of Medicinal Chemistry, , vol. 35, # 12 p. 2238 - 2243
参考文献
Journal of the American Chemical Society, , vol. 101, p. 7131 - 7134
反应条件
1-amino-1-phenylethane in hexan-1-ol T=130°C; Racemization; Kinetics; Further Variations:ReagentsSolventsTemperatures;
参考文献
Hollemann
Recueil des Travaux Chimiques des Pays-Bas, 1898 , vol. 17, p. 324