反应条件
1: rac-6-[(tetrahydro-2H-pyran-2-yl)oxy]-1-hexyne With n-butyllithium in tetrahydrofuran; hexane
T=-78°C; Substitution; 1 h;
2: 2-(4-bromobutoxy)tetrahydro-2H-pyran in tetrahydrofuran; N,N,N',N',N'',N''-hexamethylphosphoric triamide; hexane
T=20°C; Substitution; 4 h; Further stages.;
参考文献
Qin, Donghui; Sullivan, Regina; Berkowitz, William F.; Bittman, Robert; Rotenberg, Susan A.
Journal of Medicinal Chemistry, 2000 , vol. 43, # 7 p. 1413 - 1417
