[2,2']bipyridinyl; CuF2; [(diglyme)NiBr2]; cesium fluoride in N,N-dimethyl acetamide T=150°C; Inert atmosphere;

caesium carbonate; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide T=100°C; Kinetics;

1: With lithium hexamethyldisilazane in tetrahydrofuran T=-20°C; 2: With N-chloro-succinimide in tetrahydrofuran T=-20 - 20°C;

hydridotetrakis(triphenylphosphine)rhodium (Ph3P)4RhH; 1,2-bis-(diphenylphosphino)ethane in chlorobenzene 6 h; Inert atmosphereReflux;

tert.-butylhydroperoxide; tetra-(n-butyl)ammonium iodide; acetic acid in water; acetonitrile T=80°C; 2 h; Inert atmosphere;

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.83 h / -25 - -15 °C / Inert atmosphere 1.2: 3.33 h / -20 - -15 °C / Inert atmosphere 2.1: acetonitrile / Inert atmosphere 3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 23 °C / Inert atmosphere 4.1: triethylamine / isopropanol acetate / 1.25 h / 0 - 10 °C / Inert atmosphere 5.1: sitagliptin transaminase CDX-017; triethanolamine; pyridoxal 5'-phosphate; N-isopropylamine hydrochloride / water; dimethyl sulfoxide / 11 h / 40 °C / pH 9.5 / Inert atmosphere 6.1: potassium carbonate / isopropanol acetate; water / 1.25 h / 0 °C / Inert atmosphere View Scheme

1: carbon dioxide; 5-chlorobenzo[d]oxazole With caesium carbonate in N,N-dimethyl-formamide T=125°C; P=1064.07 Torr; 16 h; 2: methyl iodide in N,N-dimethyl-formamide Heating;

1: C27H37ClCuN3; potassium tert-butylate / tetrahydrofuran / 8 h / 80 °C / 760.05 Torr / Inert atmosphere; sealed tube 2: N,N-dimethyl-formamide / 1 h / 80 °C / Inert atmosphere; sealed tube View Scheme

antibody 34E4 in phosphate buffer T=20°C; pH=7.4; Kinetics; Further Variations:Reagents;

1: With copper diacetate; palladium diacetate; trifluoroacetic acid in ethylene glycol dimethyl ether T=120°C; 24 h; Inert atmosphereSealed tube; 2: With potassium carbonate in ethylene glycol dimethyl ether; water T=20°C;