外消旋N,N-二乙基-2-(羟基甲基)-1-苯基-环丙烷甲酰胺合成路线 （共 6 条）
反应条件
1: diethylamine With n-butyllithium in tetrahydrofuran; hexane T=-75°C; 1 h; 2: 1-phenyl-2-oxo-3-oxa-bicyclo(3:1:0)-hexane in tetrahydrofuran; hexane T=-78 - -60°C; 3: With water; ammonium chloride in tetrahydrofuran; hexane
参考文献
Sumitomo Chemical Company, Limited
Patent: EP1770084 A1, 2007 ;
Location in patent: Page/Page column 4 ;
EP 1770084 A1
反应条件
n-butyllithium 1) THF, hexane, 0 - -78 deg C; 2) THF, hexane, -78 deg C, 2 h; Multistep reaction;
参考文献
Roggen, Heidi; Kehler, Jan; Stensbol, Tine Bryan; Hansen, Tore
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2834 - 2837
反应条件
1: 1.) NaNH2 / 1) benzene, rt, 3 h; 2) benzene, rt, 2 h 2: aq. KOH / ethanol / 15 h / Heating 3: 1.) BuLi / 1) THF, hexane, 0 - -78 deg C; 2) THF, hexane, -78 deg C, 2 h View Scheme
参考文献
Roggen, Heidi; Kehler, Jan; Stensbol, Tine Bryan; Hansen, Tore
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 10 p. 2834 - 2837
反应条件
lithium amide in tetrahydrofuran T=-78°C;
参考文献
Shuto, Satoshi; Ono, Shizuka; Hase, Yukako; Kamiyama, Noriko; Matsuda, Akira
Tetrahedron Letters, 1996 , vol. 37, # 5 p. 641 - 644
反应条件
1: aq. KOH / ethanol / 15 h / Heating 2: 1.) BuLi / 1) THF, hexane, 0 - -78 deg C; 2) THF, hexane, -78 deg C, 2 h View Scheme
参考文献
Shuto, Satoshi; Ono, Shizuka; Hase, Yukako; Kamiyama, Noriko; Matsuda, Akira
Tetrahedron Letters, 1996 , vol. 37, # 5 p. 641 - 644
反应条件
1: aq. KOH / ethanol / 15 h / Heating 2: 1.) BuLi / 1) THF, hexane, 0 - -78 deg C; 2) THF, hexane, -78 deg C, 2 h View Scheme
参考文献
Shuto, Satoshi; Ono, Shizuka; Hase, Yukako; Kamiyama, Noriko; Takada, Hironao; Yamasihita, Kanako; Matsuda, Akira
Journal of Organic Chemistry, 1996 , vol. 61, # 3 p. 915 - 923
