2-甲基-2-苯基环己酮合成路线 （共 13 条）
参考文献
Brugidou,J. et al.
Bulletin de la Societe Chimique de France, 1979 , vol. <II>, p. 40 - 47
反应条件
in tetrahydrofuran
T=-40 - 20°C; 2.5 h;
参考文献
Ooi, Takashi; Goto, Ryoji; Maruoka, Keiji
Journal of the American Chemical Society, 2003 , vol. 125, # 35 p. 10494 - 10495
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=-45°C; 2 h; Yield given;
参考文献
Wender, Paul A.; Erhardt, Jeanette M.; Letendre, Leo J.
Journal of the American Chemical Society, 1981 , vol. 103, # 8 p. 2114 - 2116
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=-45°C; 2 h; Yield given;
参考文献
Wender, Paul A.; Erhardt, Jeanette M.; Letendre, Leo J.
Journal of the American Chemical Society, 1981 , vol. 103, # 8 p. 2114 - 2116
反应条件
lithium hexamethyldisilazane in tetrahydrofuran
T=-45°C; 2 h; Yield given;
参考文献
Wender, Paul A.; Erhardt, Jeanette M.; Letendre, Leo J.
Journal of the American Chemical Society, 1981 , vol. 103, # 8 p. 2114 - 2116
反应条件
sulfuric acid
T=-5 - 0°C;
参考文献
Maekawa, Hirofumi; Yamamoto, Yoshimasa; Shimada, Hisashi; Yonemura, Kazuaki; Nishiguchi, Ikuzo
Tetrahedron Letters, 2004 , vol. 45, # 20 p. 3869 - 3872
反应条件
diethyl ether; sodium amide; benzene
anschliessend Behandeln mit Methyljodid zuletzt bei Siedetemperatur;
参考文献
Newman; Farbman
Journal of the American Chemical Society, 1944 , vol. 66, p. 1550
反应条件
1: diethyl ether / Kochen des vom Aether befreiten Reaktionsgemisches in Benzol
2: diethyl ether; benzene; NaNH2 / anschliessend Behandeln mit Methyljodid zuletzt bei Siedetemperatur
View Scheme
参考文献
Newman; Farbman
Journal of the American Chemical Society, 1944 , vol. 66, p. 1550
反应条件
1.1: magnesium; trimethylchlorosilane / dimethylformamide / 20 °C
1.2: 44 percent / aq. sulfuric acid / methanol / 6 h / 20 °C
2.1: 82 percent / conc. sulfuric acid / -5 - 0 °C
View Scheme
参考文献
Maekawa, Hirofumi; Yamamoto, Yoshimasa; Shimada, Hisashi; Yonemura, Kazuaki; Nishiguchi, Ikuzo
Tetrahedron Letters, 2004 , vol. 45, # 20 p. 3869 - 3872
反应条件
chloro-trimethyl-silane; triethylamine
1) DMF, reflux 2) THF a) -38 deg C, 1.4 h b) -38 to 10 deg C, 3.7 h c) r.t., 1 h; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Chen, Kuanchiang; Koser, Gerald F.
Journal of Organic Chemistry, 1991 , vol. 56, # 20 p. 5764 - 5767
