3,5-二甲氧基苯甲酰氯合成路线 （共 90 条）
反应条件
T=140°C; Hydrogenation;
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1920 , vol. <2> 100, p. 177
反应条件
1: 92 percent / LiAlH4 / diethyl ether View Scheme
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1920 , vol. <2> 100, p. 177
反应条件
1.1: 11.86 g / pyridine / CH2Cl2 / 0 - 20 °C 2.1: Mg / tetrahydrofuran / 0.5 h / 20 °C 2.2: 90 percent / tetrahydrofuran / 1.5 h / 0 °C 3.1: TiCl4 / CH2Cl2 / 0.33 h / -30 °C 3.2: 59 percent / CH2Cl2 / -45 - 20 °C View Scheme
参考文献
Harrington, Paul E.; Stergiades, Ioanna A.; Erickson, Joy; Makriyannis, Alexandros; Tius, Marcus A.
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6576 - 6582
反应条件
triethylamine in chloroform T=0°C; 0.5 - 5 h;
参考文献
GLAXO GROUP LIMITED
Patent: EP1208091 B1, 2006 ;
Location in patent: Page/Page column 17; 21-22 ;
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1658 - 1666
反应条件
1: 92 percent / LiAlH4 / diethyl ether 2: 94 percent / PBr3 / CH2Cl2 3: 95 percent / 130 °C View Scheme
参考文献
Journal of Labelled Compounds and Radiopharmaceuticals, , vol. 47, # 3 p. 167 - 174
反应条件
1: 60 percent / AIBN, CBrCl3, 2-mercaptopyridine N-oxide sodium salt / 0.25 h / Heating 2: 78 percent / BBr3 / CH2Cl2 / -78 °C / to RT View Scheme
参考文献
Dol, Georg C.; Kamer, Paul C. J.; Van Leeuwen, Piet W. N. M.
European Journal of Organic Chemistry, 1998 , # 2 p. 359 - 364
反应条件
1: 93 percent / tetrahydrofuran / -20 - 20 °C 2: 83 percent / 2N KOH / 2 h / Heating 3: 50 percent / Et3SiH / trifluoroacetic acid / 24 h / 45 °C 4: 44 percent / BBr3 / CH2Cl2 / -20 - 20 °C View Scheme
参考文献
Arisawa; Ohmura; Kobayashi; Morita
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2431 - 2434
反应条件
1: 68 percent / tetrahydrofuran / -20 - 20 °C 2: 75 percent / 2N KOH / 2 h / Heating 3: 53 percent / Et3SiH / trifluoroacetic acid / 24 h / 45 °C 4: 47 percent / BBr3 / CH2Cl2 / -20 - 20 °C View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: 45 percent / tetrahydrofuran / -20 - 20 °C 2: 23 percent / 2N KOH / 2 h / Heating 3: 62 percent / Et3SiH / trifluoroacetic acid / 24 h / 45 °C 4: 38 percent / BBr3 / CH2Cl2 / -20 - 20 °C View Scheme
参考文献
Arisawa; Ohmura; Kobayashi; Morita
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2431 - 2434
