3,5-二甲氧基苯甲酰氯合成路线 （共 90 条）
反应条件
1: 2) Ag2O, H2O / 1) Et2O
2: 98 percent / LiAlH4 / tetrahydrofuran / Heating
View Scheme
参考文献
Carnmalm
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 246,249
反应条件
sodium azide; tetrabutylammomium bromide in dichloromethane; water
T=0°C; 2 h;
参考文献
Pfister, Juerg R.; Wymann, Walter E.
Synthesis, 1983 , # 1 p. 38 - 40
反应条件
3: 28.8 g / fluoroboric acid, sodium nitrite / H2O
4: 7.6 g / warming, distillation
5: 1.456 g / boron tribromide / CH2Cl2 / 52 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: diethyl ether
2: Ag2O
View Scheme
参考文献
Carnmalm
Acta Chemica Scandinavica (1947-1973), 1955 , vol. 9, p. 246,249
反应条件
1: (i) Mg(OEt)2, EtOH, Et2O, (ii) /BRN= 511839/
2: aq. NH4Cl, aq. NH3
3: (i) NaOMe, Et2O, (ii) /BRN= 506456/, Et2O, (iii) aq. H2SO4
4: polyphosphoric acid / 145 °C
View Scheme
参考文献
Hardegger,E. et al.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2543 - 2551
反应条件
1: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
2: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
3: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
4: ethanethiol, NaH / dimethylformamide / 3 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
2: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
3: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
4: ethanethiol, NaH / dimethylformamide / 3 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
sodium hydrogencarbonate in diethyl ether
参考文献
Koshy, Vettithara C.; Tandon, Shiv G.
Journal of Chemical & Engineering Data, 1981 , vol. 26, # 4 p. 421 - 423
反应条件
sodium hydrogencarbonate in diethyl ether
参考文献
Koshy, Vettithara C.; Tandon, Shiv G.
Journal of Chemical & Engineering Data, 1981 , vol. 26, # 4 p. 421 - 423
反应条件
sodium hydrogencarbonate in diethyl ether
参考文献
Koshy, Vettithara C.; Tandon, Shiv G.
Journal of Chemical & Engineering Data, 1981 , vol. 26, # 4 p. 421 - 423
