3,5-二甲氧基苯甲酰氯合成路线 （共 90 条）
反应条件
aluminium trichloride in (2S)-N-methyl-1-phenylpropan-2-amine hydrate; hexane; dichloromethane; ethyl acetate; methoxybenzene
参考文献
Celgene Corporation
Patent: US2005/107339 A1, 2005 ;
反应条件
carbon disulfide; aluminium trichloride
参考文献
James,N.F. et al.
Journal of the Chemical Society, 1963 , p. 1356 - 1363
参考文献
Mauthner
Journal fuer Praktische Chemie (Leipzig), 1913 , vol. <2> 87, p. 415
反应条件
1: 93 percent / tetrahydrofuran / -20 - 20 °C
2: 83 percent / 2N KOH / 2 h / Heating
3: 50 percent / Et3SiH / trifluoroacetic acid / 24 h / 45 °C
View Scheme
参考文献
Arisawa; Ohmura; Kobayashi; Morita
Chemical and Pharmaceutical Bulletin, 1989 , vol. 37, # 9 p. 2431 - 2434
反应条件
1: malonic acid ethyl ester monopotassium salt With triethylamine; magnesium chloride in acetonitrile
T=30°C; 0.5 h;
2: 3,5-dimethoxy-benzoyl chloride With triethylamine in acetonitrile
T=30°C;
参考文献
BIOENERGENIX
Patent: US2012/277224 A1, 2012 ;
Location in patent: Page/Page column 15 ;
US 20120277224 A1
反应条件
1: ethanolic sodium ethylate
2: aqueous ammonia
View Scheme
参考文献
Hardegger,E. et al.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2543 - 2551
参考文献
Ishida, Yohsuke; Yoshida, Yuhki; Igarashi, Tetsutaro; Sakurai, Tadamitsu
Heterocycles, 2013 , vol. 87, # 8 p. 1691 - 1698
反应条件
1: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
2: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
3: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
4: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. 859,866
反应条件
1: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
2: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
3: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
4: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
2: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
3: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
4: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
