3,5-二甲氧基苯甲酰氯合成路线 （共 90 条）
反应条件
1: diethyl ether / und Erwaermen des Reaktionsprodukts mit Essigsaeure und wss.H2SO4
2: CS2; bromine
View Scheme
参考文献
Abe et al.
Yakugaku Zasshi, 1956 , vol. 76, p. 1094
Chem.Abstr., 1957 , p. 2636
反应条件
1: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
2: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
3: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
4: NaI, ClSiMe3 / acetonitrile / 36 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: 70 percent / NaOAc, H2 / 10percent Pd-C / 2427.2 Torr / 1h, then 60 degC, overnight
2: 1.) Mg; MeI / diethyl ether / 1.) 3 h, reflux; 2.) 1 h, reflux
3: hydrogen, conc. H2SO4 / 10percent Pd-C / ethyl acetate / 4 h / 2942.03 Torr / Ambient temperature
4: ethanethiol, NaH / dimethylformamide / 3 h / Heating
View Scheme
参考文献
Ayer, William A.; Browne, Lois M.; Lovell, Sarah H.
Phytochemistry (Elsevier), 1983 , vol. 22, # 10 p. 2267 - 2272
反应条件
1: palladium/BaSO4; quinoline; sulfur / Hydrogenation.Reagens 4: Xylol
2: piperidine; 3,5-dimethoxy-benzoic acid; benzene
3: Raney nickel; aqueous ethanol / 80 °C / 22065.2 Torr / Hydrogenation
View Scheme
参考文献
Yagi
Nippon Nogei Kagaku Kaishi, 1955 , vol. 29, p. 198,200
Memoirs of the Institute of Scientific and Industrial Research, Osaka University, 1955 , vol. 12, p. 173
Chem.Abstr., 1959 , p. 303
反应条件
1: palladium/BaSO4; quinoline; sulfur / Hydrogenation.Reagens 4: Xylol
2: acetic acid anhydride; sodium acetate
3: aqueous HI; red phosphorus; acetic acid
View Scheme
参考文献
Lambooy
Journal of the American Chemical Society, 1954 , vol. 76, p. 133,135
反应条件
n-ethyl morpholine; palladium diacetate in xylene
T=120°C; decarbonylative Heck reaction; 18 h;
参考文献
Andrus, Merritt B.; Liu, Jing; Meredith, Erik L.; Nartey, Edward
Tetrahedron Letters, 2003 , vol. 44, # 26 p. 4819 - 4822
反应条件
1: (i) Mg(OEt)2, EtOH, Et2O, (ii) /BRN= 511839/
2: aq. NH4Cl, aq. NH3
3: (i) NaOMe, Et2O, (ii) /BRN= 506456/, Et2O, (iii) aq. H2SO4
4: polyphosphoric acid / 145 °C
5: NaOMe / benzene
6: (i) Et3N, benzene, (ii) KOH, MeOH
7: p-cymene / Pd-C / Heating
8: K2CO3 / acetone / Heating
View Scheme
参考文献
Hardegger,E. et al.
Helvetica Chimica Acta, 1963 , vol. 46, p. 2543 - 2551
反应条件
1.1: 11.86 g / pyridine / CH2Cl2 / 0 - 20 °C
2.1: Mg / tetrahydrofuran / 0.5 h / 20 °C
2.2: 90 percent / tetrahydrofuran / 1.5 h / 0 °C
View Scheme
参考文献
Harrington, Paul E.; Stergiades, Ioanna A.; Erickson, Joy; Makriyannis, Alexandros; Tius, Marcus A.
Journal of Organic Chemistry, 2000 , vol. 65, # 20 p. 6576 - 6582
反应条件
benzyl-N,N-dimethylamine; palladium diacetate in toluene
T=100°C; 4 h;
参考文献
Spencer, Alwyn
Journal of Organometallic Chemistry, 1983 , vol. 247, # 1 p. 117 - 122
反应条件
1: diethyl ether / Schuetteln des Reaktionsprodukts in Chloroform mit wss.HI
2: concentrated aqueous HCl; benzene; amalgamated zinc / auf dem Dampfbad
3: aqueous HI; acetic acid
4: HCl; diethyl ether / Durch Erwaermen des Reaktionsprodukts mit Wasser
View Scheme
参考文献
Brown et al.
Journal of the Chemical Society, 1949 , p. 859,866
