3,5-二甲氧基苯甲酰胺合成路线 （共 34 条）
反应条件
copper(l) iodide; (E)-1-(2-hydroxyphenyl)-3-(N,N-dimethylamino)prop-2-en-1-one; caesium carbonate in acetonitrile T=82°C; Goldberg type reaction; 12 h; Inert atmosphere;
参考文献
Cheng, Cungui; Sun, Gonglei; Wan, Jieping; Sun, Cuirong
Synlett, 2009 , # 16 p. 2663 - 2668
反应条件
2: fluoroboric acid, sodium nitrite / H2O View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 1658 - 1666
反应条件
2: 28.8 g / fluoroboric acid, sodium nitrite / H2O 3: 7.6 g / warming, distillation 4: 60 percent / lithium chips / 0.5 h View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
phosphorus pentoxide
参考文献
Hendrickson,J.B.; Schwartzman,S.M.
Tetrahedron Letters, 1975 , p. 277 - 280
反应条件
2: 28.8 g / fluoroboric acid, sodium nitrite / H2O
3: 7.6 g / warming, distillation
4: 1.) lithium / 1.) ether, 2 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
2: 28.8 g / fluoroboric acid, sodium nitrite / H2O
3: 7.6 g / warming, distillation
4: 1.) lithium / 1.) ether, 2 h
5: decarboxylation
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: diethyl ether
2: bromine
View Scheme
参考文献
Frei; Schmid
Justus Liebigs Annalen der Chemie, 1957 , vol. 603, p. 169,176
反应条件
2: 28.8 g / fluoroboric acid, sodium nitrite / H2O
3: 7.6 g / warming, distillation
4: 1.456 g / boron tribromide / CH2Cl2 / 52 h
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
反应条件
1: aqueous sodium hypobromite / -15 °C
2: potassium carbonate; diethyl ether
View Scheme
参考文献
Seka; Fuchs
Monatshefte fuer Chemie, 1931 , vol. 57, p. 52,58
反应条件
2: 28.8 g / fluoroboric acid, sodium nitrite / H2O
3: 7.6 g / warming, distillation
4: 1.) lithium / 1.) ether, 2 h
5: Cu-quinoline
6: boron tribromide, pyridine hydrochloride / CH2Cl2 / 24 h / -78 °C
View Scheme
参考文献
Durrani, Aziz A.; Tyman, John H. P.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1980 , p. 1658 - 1666
