(1S,2S)-1,2-二(2-吡啶碳酰胺)环己烷合成路线 （共 4 条）
反应条件
1: pyridine-2-carboxylic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran T=18 - 20°C; 1 h; 2: (1S,2S)-1,2-diaminocyclohexane in tetrahydrofuran T=20°C; 15 h; Further stages.;
参考文献
Conlon, David A.; Yasuda, Nobuyoshi
Advanced Synthesis and Catalysis, 2001 , vol. 343, # 1 p. 137 - 138
反应条件
lanthanum trifluoromethanesulphonate T=50°C; 24 h; Inert atmosphere; chemoselective reaction;
参考文献
Morimoto, Hiroyuki; Fujiwara, Risa; Shimizu, Yuhei; Morisaki, Kazuhiro; Ohshima, Takashi
Organic Letters, 2014 , vol. 16, # 7 p. 2018 - 2021
反应条件
N-ethyl-N,N-diisopropylamine; bis(dibenzylideneacetone)-palladium(0) in 1,4-dioxane T=80°C; 20 h; Inert atmosphereSealed vial;
参考文献
Hermange, Philippe; Lindhardt, Anders T.; Taaning, Rolf H.; Bjerglund, Klaus; Lupp, Daniel; Skrydstrup, Troels
Journal of the American Chemical Society, 2011 , vol. 133, # 15 p. 6061 - 6071
反应条件
1: benzoic acid With 1,1'-carbonyldiimidazole in tetrahydrofuran 1 h; 2: pyridine-2-carboxylic acid; (1S,2S)-1,2-diaminocyclohexane in tetrahydrofuran 4 h;
参考文献
Krska, Shane W.; Hughes, David L.; Reamer, Robert A.; Mathre, David J.; Sun, Yongkui; Trost, Barry M.
Journal of the American Chemical Society, 2002 , vol. 124, # 43 p. 12656 - 12657
