2-(2-乙氧基-2-氧代乙基)-1H-吲哚-1-羧酸叔丁酯合成路线 （共 7 条）
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane T=20°C; 2 h;
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
4-(N,N-dimethlyamino)pyridine in dichloromethane 3 h; Ambient temperature;
参考文献
Coulton, Steven; Gilchrist, Thomas L.; Graham, Keith
Journal of the Chemical Society - Perkin Transactions 1, 1998 , # 7 p. 1193 - 1202
反应条件
1: 88 percent / acetonitrile / 7 h / Heating 2: 71 percent / CH2Cl2 / 3 h 3: 70 percent / t-BuOK / toluene / 0.25 h / Heating 4: 100 percent / DMAP / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 71 percent / CH2Cl2 / 3 h 2: 70 percent / t-BuOK / toluene / 0.25 h / Heating 3: 100 percent / DMAP / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: 70 percent / t-BuOK / toluene / 0.25 h / Heating 2: 100 percent / DMAP / CH2Cl2 / 3 h / Ambient temperature View Scheme
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
in tetrahydrofuran; hexane; ethyl acetate
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
potassium hexamethylsilazane
参考文献
Gilchrist; Graham; Coulton
Tetrahedron Letters, 1995 , vol. 36, # 47 p. 8693 - 8696
