噻吩并[3,2-B]噻吩-2-甲酸合成路线 （共 14 条）
反应条件
lithium hydroxide hydrate in tetrahydrofuran; water T=100°C; 4 h;
参考文献
Kawabata, Kohsuke; Takeguchi, Masaki; Goto, Hiromasa
Macromolecules, 2013 , vol. 46, # 6 p. 2078 - 2091
反应条件
1: 81 percent / K2CO3 / dimethylformamide / 72 h / Ambient temperature 2: 90 percent / aq. LiOH / tetrahydrofuran / 3 h / Heating View Scheme
参考文献
Journal of the Chemical Society - Perkin Transactions 1, , # 22 p. 3465 - 3470
反应条件
chlorine in trichloroethane, 1,1,2- 1.) RT, 1 h, 2.) reflux, 1 h;
参考文献
Journal of medicinal chemistry, , vol. 28, # 12 p. 1896 - 1903
反应条件
1: 92.5 percent / NaOAc / acetic acid / 0.5 h / Heating 2: 93 g / 8 percent NaOH / 0.5 h / 45 - 60 °C 3: Cl2 / 1,1,2-trichloro-ethane / 1.) RT, 1 h, 2.) reflux, 1 h View Scheme
参考文献
Journal of medicinal chemistry, , vol. 28, # 12 p. 1896 - 1903
反应条件
1: 93 g / 8 percent NaOH / 0.5 h / 45 - 60 °C 2: Cl2 / 1,1,2-trichloro-ethane / 1.) RT, 1 h, 2.) reflux, 1 h View Scheme
参考文献
Journal of medicinal chemistry, , vol. 28, # 12 p. 1896 - 1903
反应条件
sodium hydroxide; iodine; potassium iodide
参考文献
Journal of the Chemical Society, , p. 305,308
反应条件
1: tin (IV)-chloride; carbon disulfide 2: potassium hexacyanoferrate(III); aqueous KOH-solution View Scheme
参考文献
Journal of the Chemical Society, , p. 305,308
反应条件
Behandeln des Reaktionsgemisches mit Kohlendioxid;
参考文献
Journal of the Chemical Society, , p. 305,308
反应条件
water; bromine; acetic acid 1.) r.t., 1 h, 2.) reflux; Yield given. Multistep reaction;
参考文献
Fuller, Lance S.; Iddon, Brian; Smith, Kevin A.
Journal of the Chemical Society - Perkin Transactions 1, 1997 , # 22 p. 3465 - 3470
反应条件
hydrogenchloride 2 h; Heating;
参考文献
Kukolja; Draheim; Graves; Hunden; Pfeil; Cooper; Ott; Counter
Journal of medicinal chemistry, 1985 , vol. 28, # 12 p. 1896 - 1903
