3-[(苄氧基)甲基]环丁醇合成路线 （共 6 条）
反应条件
L-Selectridereg; in tetrahydrofuran T=-78°C;
参考文献
Li, Yongfeng; Mao, Shuli; Hager, Michael W.; Becnel, Kimberlynne D.; Schinazi, Raymond F.; Liotta, Dennis C.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 12 p. 3398 - 3401
反应条件
L-Selectridereg; in tetrahydrofuran T=-78°C; Yield given. Yields of byproduct given;
参考文献
PFIZER LIMITED
Patent: WO2006/92691 A1, 2006 ;
Location in patent: Page/Page column 78 ;
反应条件
1: 50 percent / POCl3, Zn-Cu couple / diethyl ether / 18 h / Heating 2: 68 percent / Zn, CH3COOH / 4 h / Heating 3: L-Selectride / tetrahydrofuran / -78 °C View Scheme
参考文献
Kaiwar, Vijay; Reese, Colin B.; Gray, Emily J.; Neidle, Stephen
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 18 p. 2281 - 2288
反应条件
1: 68 percent / Zn, CH3COOH / 4 h / Heating 2: L-Selectride / tetrahydrofuran / -78 °C View Scheme
参考文献
Kaiwar, Vijay; Reese, Colin B.; Gray, Emily J.; Neidle, Stephen
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 18 p. 2281 - 2288
反应条件
1: 96 percent / NaOH, benzyltriethylammonium chloride / H2O / 12 h / Ambient temperature 2: 50 percent / POCl3, Zn-Cu couple / diethyl ether / 18 h / Heating 3: 68 percent / Zn, CH3COOH / 4 h / Heating 4: L-Selectride / tetrahydrofuran / -78 °C View Scheme
参考文献
Kaiwar, Vijay; Reese, Colin B.; Gray, Emily J.; Neidle, Stephen
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 18 p. 2281 - 2288
反应条件
1: 50 percent / Ph3P; DEAD / tetrahydrofuran / 20 °C 2: 88 percent / NaOH / dioxane / 20 °C View Scheme
参考文献
Kaiwar, Vijay; Reese, Colin B.; Gray, Emily J.; Neidle, Stephen
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995 , # 18 p. 2281 - 2288
