N,N-二-boc-4-氨基甲基苯甲腈合成路线 （共 8 条）
反应条件
sodium hydride in tetrahydrofuran 18 h; Ambient temperature;
参考文献
Lila, Christine; Gloanec, Philippe; Cadet, Laurence; Herve, Yolande; Fournier, Jean; Leborgne, Fabrice; Verbeuren, Tony J.; De Nanteuil, Guillaume
Synthetic Communications, 1998 , vol. 28, # 23 p. 4419 - 4429
反应条件
caesium carbonate; lithium iodide in tetrahydrofuran; hexane; ethyl acetate
参考文献
Schering Corporation and Pharmacopeia, Inc.
Patent: US2004/209878 A1, 2004 ;
US 20040209878 A1
反应条件
in tetrahydrofuran; water; ethyl acetate; mineral oil
参考文献
Cor Therapeutics, Inc.
Patent: US6228854 B1, 2001 ;
US 6228854 B1
反应条件
1: NBS; benzoylperoxide / CCl4 / Heating 2: NaH / tetrahydrofuran View Scheme
参考文献
Lee, Koo; Jung, Won-Hyuk; Park, Cheol Won; Park, Hee Dong; Lee, Sun Hwa; Kwon, O Hwan
Bioorganic and Medicinal Chemistry Letters, 2002 , vol. 12, # 7 p. 1017 - 1022
反应条件
hydroxylamine hydrochloride; sodium carbonate in ethanol; water 3 h; Heating;
参考文献
Lila, Christine; Gloanec, Philippe; Cadet, Laurence; Herve, Yolande; Fournier, Jean; Leborgne, Fabrice; Verbeuren, Tony J.; De Nanteuil, Guillaume
Synthetic Communications, 1998 , vol. 28, # 23 p. 4419 - 4429
反应条件
trifluoroacetic acid T=25°C; 0.25 h;
参考文献
SCHERING CORPORATION; PHARMACOPEIA, INC.
Patent: WO2004/22561 A1, 2004 ;
Location in patent: Page 113-114 ;
WO 2004/022561 A1
反应条件
hydrogenchloride in 1,4-dioxane 3 h;
参考文献
Pharmacia Corporation
Patent: US6664255 B1, 2003 ;
Location in patent: Page column 119 ;
US 6664255 B1
反应条件
sodium hydroxide in tetrahydrofuran; methanol
参考文献
Lila, Christine; Gloanec, Philippe; Cadet, Laurence; Herve, Yolande; Fournier, Jean; Leborgne, Fabrice; Verbeuren, Tony J.; De Nanteuil, Guillaume
Synthetic Communications, 1998 , vol. 28, # 23 p. 4419 - 4429
