O,O’-双(三甲基硅烷)-5-氟尿嘧啶合成路线 （共 39 条）
反应条件
toluene-4-sulfonic acid in pyridine; 1,2-dichloro-ethane T=75 - 80°C; 3 h;
参考文献
Lukevits, E.; Trushule, M.; Zarinya, D.; Ignatovich, L. M.; Liepin'sh, E.
J. Gen. Chem. USSR (Engl. Transl.), 1981 , vol. 51, # 4 p. 827 - 834,685 - 690
反应条件
tin(IV) chloride in 1,2-dichloro-ethane; acetonitrile addition at 0 deg C, stirring at 23-25 deg C, 1h;
参考文献
Iwasaki; Nishitani; Horikawa; Inoue
Tetrahedron Letters, 1981 , vol. 22, # 11 p. 1029 - 1032
反应条件
pyridine hydrochloride in chloroform T=60 - 70°C; other temperature, other solvents; Product distribution;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 51, # 4 p. 827 - 834,685 - 690
反应条件
1.) acetonitrile, 0 degC, 2.) 0 degC to R.T. 2 h; Yield given. Multistep reaction;
参考文献
Robins; Hatfield
Canadian Journal of Chemistry, 1982 , vol. 60, # 5 p. 547 - 553
反应条件
pyridine hydrochloride in chloroform T=60 - 70°C; other temperature, other solvents; Product distribution;
参考文献
J. Gen. Chem. USSR (Engl. Transl.), , vol. 51, # 4 p. 827 - 834,685 - 690
反应条件
according to the ref. 16;
参考文献
Yamashita; Yamawaki; Ueda; Yasumoto; Unemi; Hashimoto
Chemical and Pharmaceutical Bulletin, 1982 , vol. 30, # 12 p. 4258 - 4267
反应条件
trimethylsilyl trifluoromethanesulfonate in dichloromethane T=-30°C;
参考文献
Tietze, Lutz F.; Krach, Thomas; Beller, Matthias; Arlt, Michael
Chemische Berichte, 1991 , vol. 124, # 9 p. 2019 - 2024
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile 0.5 h; Ambient temperature; Yields of byproduct given;
参考文献
Ross; Springer; Vasquez; Andrews; Cook; Acevedo
Journal of Heterocyclic Chemistry, 1994 , vol. 31, # 4 p. 765 - 769
反应条件
trimethylsilyl trifluoromethanesulfonate in acetonitrile T=-5 - 0°C; 0.25 h;
参考文献
Lau; Pedersen; Jensen; Nielsen
Archiv der Pharmazie, 1991 , vol. 324, # 2 p. 83 - 89
反应条件
in 1,2-dichloro-ethane 24 h;
参考文献
Timoshchuk, V. A.; Kulinkovich, L. N.; Olimpieva, T. I.; Boreko, E. I.; Vladyko, G. V.
Pharmaceutical Chemistry Journal, 1988 , vol. 22, # 1 p. 41 - 49
Khimiko-Farmatsevticheskii Zhurnal, 1988 , vol. 22, # 1 p. 49 - 57
