1: 2,3-dichlorothiophene With n-butyllithium; diisopropylamine in tetrahydrofuran T=-78 - 0°C; 2: carbon dioxide in tetrahydrofuran T=-78 - 20°C; 0.133333 h; 3: With hydrogenchloride in tetrahydrofuran; water
参考文献
ELI LILLY AND COMPANY
Patent: EP1856090 B1, 2009 ;
Location in patent: Page/Page column 55 ;