2-(3-氯-5-(三氟甲基)吡啶-2-基)丙二酸二乙酯合成路线 （共 2 条）
反应条件
sodium hydroxide in N,N-dimethyl acetamide T=20 - 70°C; 3 h; Product distribution / selectivity;
参考文献
Lhermitte, Frederic; Coqueron, Pierre-Yves; Desbordes, Philippe; HImmler, Thomas
Patent: US2008/86008 A1, 2008 ;
Location in patent: Page/Page column 12 ;
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.17 h / 0 °C
1.2: 0 - 20 °C
2.1: hydrogen bromide; acetic acid / 3.5 h / 110 °C
3.1: hydrazine hydrate / ethanol / 3 h / 80 °C
View Scheme
参考文献
Fodor, Elena; Maftei, Catalin-Vasile; Mangalagiu, Ionel; Jones, Peter G.; Daniliuc, Constantin-Gabriel; Franz, M. Heiko; Neda, Ion
Revue Roumaine de Chimie, 2010 , vol. 55, # 9 p. 559 - 564
