[2-(2-氨基-6-氯-9H-嘌呤-9-基)乙基]丙二酸二甲酯合成路线 （共 9 条）
反应条件
tetraethylammonium chloride; N,N-dimethyl-aniline; trichlorophosphate in acetonitrile T=80°C; Substitution; 1 h;
参考文献
Hijiya, Toyoto; Yamashita, Keizo; Kojima, Mitsuhiko; Uchida, Yumiko; Katayama, Satoshi; Torii, Takayoshi; Shiragami, Hiroshi; Izawa, Kunisuke
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 653 - 654
反应条件
1.1: 74 percent / dimethylformamide; H2O / 8 h / 70 °C 2.1: H2; NaHCO3 / Pd/C / methanol; H2O / 19 h / 50 °C / 760.05 Torr 2.2: 90 percent / aq. NaOH / methanol / 2 h / 60 °C 3.1: 95 percent / thionyl chloride / 40 - 45 °C 4.1: 70 percent / tetraethylammonium chloride; phosphorus oxychloride / acetonitrile / 1 h / 80 °C View Scheme
参考文献
Hijiya, Toyoto; Yamashita, Keizo; Kojima, Mitsuhiko; Uchida, Yumiko; Katayama, Satoshi; Torii, Takayoshi; Shiragami, Hiroshi; Izawa, Kunisuke
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 653 - 654
反应条件
1.1: H2; NaHCO3 / Pd/C / methanol; H2O / 19 h / 50 °C / 760.05 Torr 1.2: 90 percent / aq. NaOH / methanol / 2 h / 60 °C 2.1: 95 percent / thionyl chloride / 40 - 45 °C 3.1: 70 percent / tetraethylammonium chloride; phosphorus oxychloride / acetonitrile / 1 h / 80 °C View Scheme
参考文献
Hijiya, Toyoto; Yamashita, Keizo; Kojima, Mitsuhiko; Uchida, Yumiko; Katayama, Satoshi; Torii, Takayoshi; Shiragami, Hiroshi; Izawa, Kunisuke
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 653 - 654
反应条件
1: 95 percent / thionyl chloride / 40 - 45 °C 2: 70 percent / tetraethylammonium chloride; phosphorus oxychloride / acetonitrile / 1 h / 80 °C View Scheme
参考文献
Hijiya, Toyoto; Yamashita, Keizo; Kojima, Mitsuhiko; Uchida, Yumiko; Katayama, Satoshi; Torii, Takayoshi; Shiragami, Hiroshi; Izawa, Kunisuke
Nucleosides and Nucleotides, 1999 , vol. 18, # 4-5 p. 653 - 654
反应条件
potassium carbonate 1.) DMF, 60 deg C, 22 h, 2.) MeOH, 15-20 deg C, 1.5 h; Yield given. Multistep reaction;
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
1: NaBH4 / CH2Cl2; methanol / 3.5 h / 20 - 22 °C 2: 65 percent / Et3N, DMAP / CH2Cl2 / 2 h / Heating 3: 94 percent / aq. HCl / 3 h / Heating View Scheme
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
1: NaBH4 / CH2Cl2; methanol / 3.5 h / 20 - 22 °C 2: 65 percent / Et3N, DMAP / CH2Cl2 / 2 h / Heating View Scheme
参考文献
Choudary, Bernadette M.; Geen, Graham R.; Kincey, Peter M.; Parratt, Martin J.; Dales, J. Robert M.; Johnson, Graham P.; O'Donnell, Steven; Tudor, David W.; Woods, Neil
Nucleosides and Nucleotides, 1996 , vol. 15, # 5 p. 981 - 994
反应条件
1: NaBH4 / CH2Cl2; methanol / 3.5 h / 20 - 22 °C 2: 65 percent / Et3N, DMAP / CH2Cl2 / 2 h / Heating 3: 81 percent / Et3N, H2 / Pd-C / ethyl acetate / 4 h / 50 °C / 750.06 Torr View Scheme
参考文献
Nucleosides and Nucleotides, , vol. 15, # 5 p. 981 - 994
反应条件
sodium tetrahydroborate in methanol; dichloromethane T=20 - 22°C; 3.5 h;
参考文献
Nucleosides and Nucleotides, , vol. 15, # 5 p. 981 - 994
