(2,3-二氢-苯并[1,4]二氧-6)-乙酸合成路线 （共 5 条）
反应条件
1: With morpholine; sulfur T=140°C; 14 h; 2: With potassium hydroxide in water 12 h; Reflux; 3: With hydrogenchloride in water pH=2;
参考文献
SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH; CHIOSIS, Gabriela; TALDONE, Tony; SUN, Weilin
Patent: WO2011/44394 A1, 2011 ;
Location in patent: Page/Page column 113-114 ;
反应条件
1: With hydrazine hydrate; potassium hydroxide T=0 - 110°C; 2: With hydrogenchloride T=0°C; pH=~ 3 - 4;
参考文献
GRUeNENTHAL GMBH; FRANK, Robert; BAHRENBERG, Gregor; CHRISTOPH, Thomas; SCHIENE, Klaus; DE VRY, Jean; DAMANN, Nils; FRORMANN, Sven; LESCH, Bernhard; LEE, Jeewoo; KIM, Yong-Soo; KIM, Myeong-Seop
Patent: WO2010/127855 A1, 2010 ;
Location in patent: Page/Page column 116; 117 ;
反应条件
1: 6-bromo-2,3-dihydro-1,4-benzodioxine With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 1 h; 2: monobromoacetic acid in tetrahydrofuran; hexane T=-78 - 20°C; Further stages.;
参考文献
Harrak; Rosell; Daidone; Plescia; Schillaci; Pujol
Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 14 p. 4876 - 4890
反应条件
1: 91 percent / AlCl3 / CS2 / 10 h / Ambient temperature 2: S8 3: aq. NaOH View Scheme
参考文献
Vazquez; Rosell; Pujol
Farmaco, 1996 , vol. 51, # 3 p. 215 - 217
反应条件
potassium hydroxide 7 h; Heating;
参考文献
Vazquez; Rosell; Pujol
Farmaco, 1996 , vol. 51, # 3 p. 215 - 217
