(S)-(-)-α-甲氧基-α-(三氟甲基)苯乙酸合成路线 （共 24 条）
反应条件
2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; sodium chlorite in phosphate buffer; acetonitrile T=55°C; 4 h;
参考文献
Moreno-Dorado, F. Javier; Guerra, Francisco M.; Ortega, Maria J.; Zubia, Eva; Massanet, Guillermo M.
Tetrahedron Asymmetry, 2003 , vol. 14, # 4 p. 503 - 510
反应条件
1.1: 52 percent 2.1: 73 percent / NaH / tetrahydrofuran / 20 °C 3.1: O3 / CH2Cl2 / -78 °C 3.2: 54 percent / Me2S / CH2Cl2 / -78 - 20 °C 4.1: NaClO2; KH2PO4; isobutene / 2-methyl-propan-2-ol; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 24 p. 8846 - 8854
反应条件
1.1: 73 percent / NaH / tetrahydrofuran / 20 °C 2.1: O3 / CH2Cl2 / -78 °C 2.2: 54 percent / Me2S / CH2Cl2 / -78 - 20 °C 3.1: NaClO2; KH2PO4; isobutene / 2-methyl-propan-2-ol; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 24 p. 8846 - 8854
反应条件
1.1: O3 / CH2Cl2 / -78 °C 1.2: 54 percent / Me2S / CH2Cl2 / -78 - 20 °C 2.1: NaClO2; KH2PO4; isobutene / 2-methyl-propan-2-ol; H2O / 16 h / 20 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 64, # 24 p. 8846 - 8854
反应条件
lithium hydroxide; dihydrogen peroxide in tetrahydrofuran; water T=20°C; 12 h;
参考文献
Tetrahedron Asymmetry, , vol. 19, # 10 p. 1274 - 1284
参考文献
Journal of the American Chemical Society, , vol. 92, p. 875 - 886
反应条件
2: Ag2O 3: aq. H2SO4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 92, p. 875 - 886
反应条件
1: Ag2O 2: aq. H2SO4 View Scheme
参考文献
Journal of the American Chemical Society, , vol. 92, p. 875 - 886
反应条件
1: With (1S,2R)-1-aminoindan-2-ol in ethanol; ethyl acetate T=30°C; Addition; 12 h; 2: With hydrogenchloride Hydrolysis; Further stages.;
参考文献
Journal of the Chemical Society. Perkin Transactions 2, , # 1 p. 111 - 119
反应条件
1: 91 percent / NaH / dimethylformamide View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 13 p. 4216 - 4218
