1-(6-氯哒嗪-3-基)吗啉合成路线 （共 3 条）
反应条件
triethylamine in N,N-dimethyl-formamide T=80°C;
参考文献
Sengmany, Stephane; Vitu-Thiebaud, Arnaud; Le Gall, Erwan; Condon, Sylvie; Leonel, Eric; Thobie-Gautier, Christine; Pipelier, Muriel; Lebreton, Jacques; Dubreuil, Didier
Journal of Organic Chemistry, 2013 , vol. 78, # 2 p. 370 - 379
反应条件
(2,2′-bipyridine)nickel(II) dibromide; tetrabutylammomium bromide in ethylene dibromide; N,N-dimethyl-formamide T=20°C; 4 h; Electrochemical reactionInert atmosphere;
参考文献
Journal of Organic Chemistry, , vol. 78, # 2 p. 370 - 379
反应条件
1: 1.) NH2NH2*H2O / 1.) butanol, 98 deg C, 48 h, 2.) H2O, reflux, 30 min
2: 1.) NaH / 1.) DMF, 55 deg C, 30 min, 2.) DMF, 55 deg C, 90 min
3: 85 percent / 3percent HCl
4: 0.05 g / H2, acetic acid / PtO2 / 10 h / 760 Torr
View Scheme
参考文献
Bellasio; Campi; Di Mola; Baldoli
Journal of Medicinal Chemistry, 1984 , vol. 27, # 8 p. 1077 - 1083
