5-甲氧基-1H-吲哚-3-甲酸甲酯合成路线 (共 3 条)
反应条件
acetic acid T=70°C; 4.5 h;
参考文献
SANWA KAGAKU KENKYUSHO CO., LTD.
Patent: EP1595866 A1, 2005 ;
Location in patent: Page/Page column 18 ;
反应条件
1: 5-Methoxy-1H-indole; 2,2,2-trichloroacetyl chloride With pyridine in tetrahydrofuran T=0 - 20°C; Inert atmosphere; 2: methanol With potassium hydroxide; water RefluxInert atmosphere;
参考文献
Linton, Elizabeth C.; Kozlowski, Marisa C.
Journal of the American Chemical Society, 2008 , vol. 130, # 48 p. 16162 - 16163
反应条件
carbon monoxide; [Rh(CO)2(Me2NCH2CH2NMe2)][RhCl2(CO)2] in tetrahydrofuran T=100°C; P=5171.62 Torr; 20 h; Autoclave;
参考文献
Okuro, Kazumi; Gurnham, Joanna; Alper, Howard
Journal of Organic Chemistry, 2011 , vol. 76, # 11 p. 4715 - 4720