tri[2-(2-methoxyethoxy)ethyl]amine; copper(l) chloride in 1,4-dioxane 0.666667 h; microwawe irradiation;
参考文献
Coelho, Paulo J.; Carvalho, Luis M.; Silva, Jose C.; Oliveira-Campos, Ana M.F.; Samat, Andre; Guglielmetti, Robert
Helvetica Chimica Acta, 2001 , vol. 84, # 1 p. 117 - 123
1: chloro-diphenylphosphine With sodium in tetrahydrofuran T=65 - 66°C; 2 h; Industry scale; 2: o-chloro-sodium benzoate in tetrahydrofuran T=25°C; 10 h; Industry scale; 3: in tetrahydrofuran Acidic conditionsIndustry scale; Product distribution / selectivity;
1: CuCl; tris[2-(2-methoxyethoxy)ethyl]amine / dioxane / 0.67 h / microwawe irradiation
2: polyphosphoric acid / 24 h / 60 °C
3: 89 percent / AlCl3 / benzene / 1 h / Heating
View Scheme
参考文献
Coelho, Paulo J.; Carvalho, Luis M.; Silva, Jose C.; Oliveira-Campos, Ana M.F.; Samat, Andre; Guglielmetti, Robert
Helvetica Chimica Acta, 2001 , vol. 84, # 1 p. 117 - 123
Rewcastle, Gordon W.; Atwell, Graham J.; Baguley, Bruce C.; Calveley, Stephen B.; Denny, William A.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 4 p. 793 - 799
