2-(羟基甲基)吲哚啉-1-羧酸叔丁酯合成路线 （共 7 条）
反应条件
borane-THF in tetrahydrofuran T=20°C;
参考文献
Lee, Sunkyung; Yi, Kyu Yang; Kim, Soo-Kyung; Suh, Jeehee; Kim, Nak Jeong; Yoo, Sung-Eun; Lee, Byung Ho; Seo, Ho Won; Kim, Sun-Ok; Lim, Hong
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 459 - 471
反应条件
1: 1.) Mg, MeOH, 2.) LiAlH4 / 2.) Et2O 2: aq. NaHCO3 / CH2Cl2 View Scheme
参考文献
Journal of Organic Chemistry, , vol. 61, # 8 p. 2897 - 2900
反应条件
sodium hydrogencarbonate in dichloromethane
参考文献
Journal of Organic Chemistry, , vol. 61, # 8 p. 2897 - 2900
反应条件
1: 94.2 percent / Et3N / tetrahydrofuran / 20 °C 2: 96 percent / BH3*THF / tetrahydrofuran / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 38, # 5 p. 459 - 471
反应条件
1: 94.2 percent / Et3N / tetrahydrofuran / 20 °C 2: 96 percent / BH3*THF / tetrahydrofuran / 20 °C View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 38, # 5 p. 459 - 471
反应条件
1: 61 percent / NaH / tetrahydrofuran / 0 - 20 °C
2: 87 percent / CF3COOH / CH2Cl2 / 20 h / 20 °C
View Scheme
参考文献
Lee, Sunkyung; Yi, Kyu Yang; Kim, Soo-Kyung; Suh, Jeehee; Kim, Nak Jeong; Yoo, Sung-Eun; Lee, Byung Ho; Seo, Ho Won; Kim, Sun-Ok; Lim, Hong
European Journal of Medicinal Chemistry, 2003 , vol. 38, # 5 p. 459 - 471
反应条件
1: 91 percent / Dess-Martin reagent / CH2Cl2
2: NH4OAc; AcOH
3: TFA
View Scheme
参考文献
Breslin, Henry J.; Miskowski, Tamara A.; Kukla, Michael J.; De Winter, Hans L.; Somers, Maria V. F.; Roevens, Peter W. M.; Kavash, Robert W.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 24 p. 4467 - 4471
