(S)-N-BOC-2-氨基-4-甲基戊烷氰合成路线 （共 13 条）
反应条件
potassium hydroxide in ethanol; water T=90°C; Inert atmosphere;
参考文献
Xin, Dongyue; Perez, Lisa M.; Ioerger, Thomas R.; Burgess, Kevin
Angewandte Chemie - International Edition, 2014 , vol. 53, # 14 p. 3594 - 3598
Angew. Chem., 2014 , vol. 126, # 14 p. 3668 - 3672,5
反应条件
hydrogenchloride 12 h; Heating;
参考文献
Journal of Organic Chemistry, , vol. 63, # 22 p. 7764 - 7769
反应条件
sodium chloride in water; N,N-dimethyl-formamide
参考文献
Ohmoto, Kazuyuki; Itagaki, Iori
Patent: US2003/166573 A1, 2003 ;
反应条件
1: Et3N, DMAP / CH2Cl2 / Ambient temperature
2: dimethylformamide / 24 h / Ambient temperature
View Scheme
参考文献
Sutherland, Andrew; Willis, Christine L.
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7764 - 7769
反应条件
in dichloromethane
4 h; Heating;
参考文献
Caputo, Romualdo; Cassano, Ersilia; Longobardo, Luigi; Palumbo, Giovanni
Tetrahedron, 1995 , vol. 51, # 45 p. 12337 - 12350
反应条件
1: 1.) Et3N, EtOCOCl, 2.) NaBH4 / 1.) THF, 0 deg C, 0.25 h, 2.) H2O, 0 deg C, 0.5 h, room temperature, 2 h
2: Et3N, DMAP / CH2Cl2 / Ambient temperature
3: dimethylformamide / 24 h / Ambient temperature
View Scheme
参考文献
Sutherland, Andrew; Willis, Christine L.
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7764 - 7769
反应条件
1: 89 percent / aq. sodium hydroxide / 1.) 0 deg C, 0.5 h, 2.) room temperature, 2 h
2: 1.) Et3N, EtOCOCl, 2.) NaBH4 / 1.) THF, 0 deg C, 0.25 h, 2.) H2O, 0 deg C, 0.5 h, room temperature, 2 h
3: Et3N, DMAP / CH2Cl2 / Ambient temperature
4: dimethylformamide / 24 h / Ambient temperature
View Scheme
参考文献
Sutherland, Andrew; Willis, Christine L.
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7764 - 7769
反应条件
1: 89 percent / aq. sodium hydroxide / 1.) 0 deg C, 0.5 h, 2.) room temperature, 2 h
2: 1.) Et3N, EtOCOCl, 2.) NaBH4 / 1.) THF, 0 deg C, 0.25 h, 2.) H2O, 0 deg C, 0.5 h, room temperature, 2 h
3: Et3N, DMAP / CH2Cl2 / Ambient temperature
4: dimethylformamide / 24 h / Ambient temperature
View Scheme
参考文献
Sutherland, Andrew; Willis, Christine L.
Journal of Organic Chemistry, 1998 , vol. 63, # 22 p. 7764 - 7769
反应条件
1: 90 percent / triethylamine / tetrahydrofuran / 2 h
2: 90 percent / polystyryl diphenylphosphine, imidazole, iodine / CH2Cl2 / 1 h / Heating
3: 82 percent / CH2Cl2 / 4 h / Heating
View Scheme
参考文献
Caputo, Romualdo; Cassano, Ersilia; Longobardo, Luigi; Palumbo, Giovanni
Tetrahedron, 1995 , vol. 51, # 45 p. 12337 - 12350
反应条件
in dimethyl sulfoxide
T=45°C; 12 h;
参考文献
Sohtome, Yoshihiro; Shin, Bongki; Horitsugi, Natsuko; Takagi, Rika; Noguchi, Keiichi; Nagasawa, Kazuo
Angewandte Chemie - International Edition, 2010 , vol. 49, # 40 p. 7299 - 7303
