4-羟基-4-苯基哌啶-1-羧酸叔丁酯合成路线 （共 15 条）
反应条件
in dichloromethane T=20°C; 5 h;
参考文献
ORTHO-MCNEIL-JANSSEN PHARMACEUTICALS, INC.; ADDEX PHARMA S.A.
Patent: WO2009/33704 A1, 2009 ;
Location in patent: Page/Page column 38 ;
WO 2009/033704 A1
反应条件
sodium carbonate in 1,4-dioxane; water T=20°C; 4 h;
参考文献
Meiji Seika Kaisha, Ltd.
Patent: US6355642 B1, 2002 ;
Location in patent: Page column 30 ;
反应条件
1: in tetrahydrofuran T=-50°C; 1.5 h; 2: With ammonium chloride
参考文献
GALDERMA RESEARCH andamp; DEVELOPMENT; BOUIX-PETER, Claire; SUZUKI, Itaru; PELISSON, Isabelle; COLLETTE, Pascal; TABET, Samuel; LAFITTE, Guillaume
Patent: WO2010/52255 A1, 2010 ;
Location in patent: Page/Page column 57 ;
WO 2010/052255 A1
反应条件
bis(1,5-cyclooctadiene)nickel (0); potassium tert-butylate; chlorobenzene; cesium fluoride; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride in toluene T=80°C; 0.5 h; Inert atmosphere;
参考文献
Berini, Christophe; Navarro, Oscar
Chemical Communications, 2012 , vol. 48, # 10 p. 1538 - 1540
反应条件
iodosylbenzene; iodine in acetonitrile 11 h; IrradiationHeating;
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
1: 94 percent / Et3N / CH2Cl2 / 20 °C 2: 53 percent / diisobutylaluminum hydrire (DIBAL-H) / toluene / 4 h / -78 °C 3: 95 percent / aq. NaH2PO4; H2O2; aq. NaClO2 / acetonitrile 4: 81 percent / PhIO; I2 / acetonitrile / 11 h / Irradiation; Heating View Scheme
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
1: 94 percent / Et3N / CH2Cl2 / 20 °C 2: 53 percent / diisobutylaluminum hydrire (DIBAL-H) / toluene / 4 h / -78 °C 3: 95 percent / aq. NaH2PO4; H2O2; aq. NaClO2 / acetonitrile 4: 81 percent / PhIO; I2 / acetonitrile / 11 h / Irradiation; Heating View Scheme
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
1: 53 percent / diisobutylaluminum hydrire (DIBAL-H) / toluene / 4 h / -78 °C 2: 95 percent / aq. NaH2PO4; H2O2; aq. NaClO2 / acetonitrile 3: 81 percent / PhIO; I2 / acetonitrile / 11 h / Irradiation; Heating View Scheme
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
1: 95 percent / aq. NaH2PO4; H2O2; aq. NaClO2 / acetonitrile 2: 81 percent / PhIO; I2 / acetonitrile / 11 h / Irradiation; Heating View Scheme
参考文献
Boto, Alicia; Hernandez, Rosendo; De Leon, Yolanda; Murguia, Jose R.; Rodriguez-Afonso, Abigail
European Journal of Organic Chemistry, 2005 , # 4 p. 673 - 682
反应条件
1: C6H5Hal With magnesium in tetrahydrofuran 2: tert-butyl 4-oxo-piperidine-1-carboxylate in tetrahydrofuran
参考文献
Kumagai, Toshihito; Okubo, Taketoshi; Kataoka-Okubo, Hiromi; Chaki, Shigeyuki; Okuyama, Shigeru; Nakazato, Atsuro
Bioorganic and Medicinal Chemistry, 2001 , vol. 9, # 5 p. 1357 - 1363
