4-羟基-4-苯基哌啶-1-羧酸叔丁酯合成路线 （共 15 条）
反应条件
1: toluene / Reflux; Inert atmosphere 2: bis(1,5-cyclooctadiene)nickel (0); potassium tert-butylate; chlorobenzene; cesium fluoride; 1,3-bis(2,6-diisopropylphenyl)imidazolinium chloride / toluene / 0.5 h / 80 °C / Inert atmosphere View Scheme
参考文献
Berini, Christophe; Navarro, Oscar
Chemical Communications, 2012 , vol. 48, # 10 p. 1538 - 1540
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
反应条件
hydrogenchloride in ethyl acetate T=20°C;
参考文献
PRESIDENT AND FELLOWS OF HARVARD COLLEGE; SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY; YUAN, Junying; YUAN, Chengye; CHEN, Gang; XIA, Hong-guang
Patent: WO2011/143444 A2, 2011 ;
Location in patent: Page/Page column 7; 84-85 ;
反应条件
1: HCl; AcOH 2: HCl 3: NaOH View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 13, # 22 p. 3951 - 3954
参考文献
Chen, Jian Jeffrey; Dewdney, Nolan; Lin, Xiaohong; Martin, Robert L.; Walker, Keith A. M.; Huang, Jane; Chu, Frances; Eugui, Elsie; Mirkovich, Anna; Kim, Yong; Sarma, Keshab; Arzeno, Humberto; Van Wart, Harold E.
Bioorganic and Medicinal Chemistry Letters, 2003 , vol. 13, # 22 p. 3951 - 3954
