5-溴-N,N-二甲基色胺合成路线 （共 5 条）
反应条件
hydrogen; palladium on activated charcoal in methanol 18 h;
参考文献
Djura; Stierle; Sullivan; et al.
Journal of Organic Chemistry, 1980 , vol. 45, # 8 p. 1435 - 1441
反应条件
1,1'-bis(diphenylphosphino)ferrocene; zink cyanide; tris(dibenzylideneacetone)dipalladium(0) chloroform complex in DMF (N,N-dimethyl-formamide) T=110°C; 21 h;
参考文献
CIBA SPECIALTY CHEMICALS HOLDING INC.
Patent: WO2004/56769 A2, 2004 ;
Location in patent: Page 55 ;
反应条件
1,1'-bis-(diphenylphosphino)ferrocene; tris-(dibenzylideneacetone)dipalladium(0) in DMF (N,N-dimethyl-formamide); chloroform T=110°C; 21 h; Product distribution / selectivity;
参考文献
RATIOPHARM GMBH
Patent: WO2005/75422 A1, 2005 ;
Location in patent: Page/Page column 35 ;
反应条件
1: in 1-methyl-pyrrolidin-2-one T=200°C; 9 h; 2: With ammonia in water T=20°C; Product distribution / selectivity;
参考文献
RATIOPHARM GMBH
Patent: WO2005/75422 A1, 2005 ;
Location in patent: Page/Page column 40-41 ;
反应条件
1: With tris-(dibenzylideneacetone)dipalladium(0) in tetrahydrofuran
T=20°C; 0.0833333 h;
2: With lithium hexamethyldisilazane in tetrahydrofuran
T=20°C; 21 h; Heating / reflux;
3: With hydrogenchloride; sodium hydroxide; water
more than 3 stages;
参考文献
Maddaford, Shawn; Ramnauth, Jailall; Rakhit, Suman; Patman, Joanne; Renton, Paul; Annedi, Subhash C.
Patent: US2006/258721 A1, 2006 ;
Location in patent: Page/Page column 43 ;
US 20060258721 A1
