2-氨基-3-溴-5-甲基吡啶合成路线 （共 23 条）
反应条件
hydrogen bromide; dihydrogen peroxide T=70°C; 1 h; Product distribution;
参考文献
Dunn, A. D.; Currie, A.; Hayes, L. E.
Journal fuer Praktische Chemie (Leipzig), 1989 , vol. 331, # 3 p. 369 - 374
反应条件
1.1: 12.7 percent / 3.5 h / 200 °C 2.1: POCl3 / 18 h / Heating 2.2: 38.8 percent / ethanol / 1 h / Heating View Scheme
参考文献
Zhao, Yunqi; Duan, Shaofeng; Zeng, Xing; Liu, Chunjing; Davies, Neal M.; Li, Benyi; Forrest, M. Laird
Molecular Pharmaceutics, 2012 , vol. 9, # 6 p. 1705 - 1716
反应条件
triethylamine; triphenylphosphine; palladium diacetate in N,N-dimethyl-formamide T=50°C; 16 h;
参考文献
Abbiati, Giorgio; Arcadi, Antonio; Marinelli, Fabio; Rossi, Elisabetta
Synthesis, 2002 , # 13 p. 1912 - 1916
反应条件
1: in ethylene glycol dimethyl ether; water T=20°C; 24 h; 2: in ethanol 24 h; Heating;
参考文献
Kazock, Jean-Yves; Enguehard-Gueiffier, Cecile; Thery, Isabelle; Gueiffier, Alain
Bulletin of the Chemical Society of Japan, 2005 , vol. 78, # 1 p. 154 - 159
反应条件
in dichloromethane T=0 - 20°C; 48 h;
参考文献
Zhao, Yunqi; Duan, Shaofeng; Zeng, Xing; Liu, Chunjing; Davies, Neal M.; Li, Benyi; Forrest, M. Laird
Molecular Pharmaceutics, 2012 , vol. 9, # 6 p. 1705 - 1716
参考文献
Knight, Zachary A.; Chiang, Gary G.; Alaimo, Peter J.; Kenski, Denise M.; Ho, Caroline B.; Coan, Kristin; Abraham, Robert T.; Shokat, Kevan M.
Bioorganic and Medicinal Chemistry, 2004 , vol. 12, # 17 p. 4749 - 4759
反应条件
1.1: dichloromethane / 20 °C 2.1: methanesulfonyl chloride; triethylamine 3.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; N-ethyl-N,N-diisopropylamine 3.2: 20 °C 4.1: toluene / 4 h / Reflux; Molecular sieve; Inert atmosphere 5.1: sodium tetrahydroborate / methanol / 1 h / 0 - 20 °C View Scheme
参考文献
Molecular Pharmaceutics, , vol. 8, # 3 p. 901 - 912
反应条件
sulfuric acid; sulfur trioxide; dihydrogen peroxide 1.) 8 deg C, overnight, 2.) 20 deg C, 48 h;
参考文献
Lindstroem, Stefan; Ahmad, Tania; Grivas, Spiros
Heterocycles, 1994 , vol. 38, # 3 p. 529 - 540
反应条件
in ethanol 24 h; Reflux;
参考文献
Veron, Jean-Baptiste; Allouchi, Hassan; Enguehard-Gueiffier, Cecile; Snoeck, Robert; Andrei, Graciela; De Clercq, Erik; Gueiffier, Alain
Bioorganic and Medicinal Chemistry, 2008 , vol. 16, # 21 p. 9536 - 9545
反应条件
hydrogenchloride; sodium hydrogencarbonate 1) H2O, a) r.t., b) 80 deg C, 2) r.t.; Yield given. Multistep reaction;
参考文献
Yamanaka; Miyake; Suda; Ohhara; Ogawa
Chemical and Pharmaceutical Bulletin, 1991 , vol. 39, # 6 p. 1556 - 1567
