2-氯-3-溴-5-甲基吡啶合成路线 （共 4 条）
反应条件
1: With hydrogenchloride; sodium nitrite in water T=0°C; 2: With ammonia in water
参考文献
WO2006/25783 A1, ;
Page/Page column 144 ;
WO 2006/025783 A1
反应条件
1: With trichlorophosphate 20 h; Heating / reflux; 2: With sodium hydroxide; water T=0°C; pH=8.5;
参考文献
US2006/229326 A1, ;
Page/Page column 20 ;
US 20060229326 A1
反应条件
in methanol T=65°C; 32 h; Inert atmosphere;
参考文献
NOVARTIS AG; Cotesta, Simona; Furet, Pascal; Guagnano, Vito; Holzer, Philipp; Kallen, Joerg; Mah, Robert; Masuya, Keiichi; Schlapbach, Achim; Stutz, Stefan; Vaupel, Andrea
Patent: US2013/317024 A1, 2013 ;
Location in patent: Paragraph 0839; 0840 ;
反应条件
potassium permanganate in water
参考文献
Andjelkovic, Mirjana; Benardeau, Agnes; Chaput, Evelyne; Hebeisen, Paul; Nettekoven, Matthias; Sander, Ulrike Obst; Panousis, Constantinos G.; Roever, Stephan
Patent: US2008/85906 A1, 2008 ;
Location in patent: Page/Page column 16 ;
