1: 2-Chloro-3-fluoro-pyridine With lithium diisopropyl amide in tetrahydrofuran; n-heptane; ethylbenzene T=-78°C; 3.33333 h; 2: carbon dioxide in tetrahydrofuran; n-heptane; ethylbenzene T=0°C; 1.33333 h; 3: With hydrogenchloride in water pH=2;
参考文献
MERCK SHARP and DOHME LIMITED
Patent: WO2003/99816 A1, 2003 ;
Location in patent: Page 61 ;
WO 03/099816 A1