N-环戊基-N-[(1,1-二甲基乙氧基)羰基]-甘氨酸合成路线 （共 5 条）
反应条件
1: monobromoacetic acid; (cyclopent-1-yl)amine in diethyl ether T=0°C; 2: di-tert-butyl dicarbonate With triethylamine in 1,4-dioxane; water T=20°C; 5 h;
参考文献
AIC
Patent: WO2004/76433 A1, 2004 ;
Location in patent: Page 76; Figure 3 ;
WO 2004/076433 A1
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2223.7 Torr; 24 h; Ambient temperature; Yield given;
参考文献
Goodfellow, Val S.; Marathe, Manoj V.; Kuhlman, Karen G.; Fitzpatrick, Timothy D.; Cuadrado, David; Hanson, Wendy; Zuzack, John S.; Ross, Sherman E.; Wieczorek, Maciej; Burkard, Michael; Whalley, Eric T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1472 - 1484
反应条件
1: 1 N aq. NaOH / dioxane / 15 h 2: H2 / 10percent Pd/C / ethanol / 24 h / 2223.7 Torr / Ambient temperature View Scheme
参考文献
Goodfellow, Val S.; Marathe, Manoj V.; Kuhlman, Karen G.; Fitzpatrick, Timothy D.; Cuadrado, David; Hanson, Wendy; Zuzack, John S.; Ross, Sherman E.; Wieczorek, Maciej; Burkard, Michael; Whalley, Eric T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1472 - 1484
反应条件
1: tetrahydrofuran / 15 h / Ambient temperature 2: 1 N aq. NaOH / dioxane / 15 h 3: H2 / 10percent Pd/C / ethanol / 24 h / 2223.7 Torr / Ambient temperature View Scheme
参考文献
Goodfellow, Val S.; Marathe, Manoj V.; Kuhlman, Karen G.; Fitzpatrick, Timothy D.; Cuadrado, David; Hanson, Wendy; Zuzack, John S.; Ross, Sherman E.; Wieczorek, Maciej; Burkard, Michael; Whalley, Eric T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1472 - 1484
反应条件
1: 1 N aq. NaOH / dioxane / 15 h 2: H2 / 10percent Pd/C / ethanol / 24 h / 2223.7 Torr / Ambient temperature View Scheme
参考文献
Goodfellow, Val S.; Marathe, Manoj V.; Kuhlman, Karen G.; Fitzpatrick, Timothy D.; Cuadrado, David; Hanson, Wendy; Zuzack, John S.; Ross, Sherman E.; Wieczorek, Maciej; Burkard, Michael; Whalley, Eric T.
Journal of Medicinal Chemistry, 1996 , vol. 39, # 7 p. 1472 - 1484
