4-氮杂吲哚-2-甲酸乙酯合成路线 （共 20 条）
反应条件
palladium 10 on activated carbon; ammonium formate; acetic acid in ethanol; water T=35°C; 3.25 h; Large scale reaction;
参考文献
Huang, Bao-Guo; Kubiak, Gregory; Shay, John J.; Pemberton, Clive; Peers, James; Hanna, Reda G.; Powers, Matthew R.; Gamboa, Juan A.; Gelormini, Ann M.; Yarabe, Hyacinthe; Rudisill, Duane E.
Organic Process Research and Development, 2011 , vol. 15, # 5 p. 1040 - 1045
反应条件
hydrogen; palladium 10 on activated carbon in ethanol P=1034.32 - 1551.49 Torr; 12 h;
参考文献
WO2004/104001 A2, ;
Page 42 ;
WO 2004/104001 A2
反应条件
iron; acetic acid in ethanol 2 h; Heating / reflux;
参考文献
CELLTECH R and D LIMITED
Patent: WO2004/31188 A1, 2004 ;
Location in patent: Page 43 ;
WO 2004/031188 A1
反应条件
1: With pyridine; ethyl orthosilicate; pyridinium p-toluenesulfonate T=20°C; 24 h; 2: With tetrakis(triphenylphosphine) palladium(0); N,N-dicyclohexylmethylamine T=160°C; 0.333333 h; Microwave irradiation;
参考文献
Engelhardt, Harald; De Esch, Iwan J.P.; Kuhn, Daniel; Smits, Rogier A.; Zuiderveld, Obbe P.; Dobler, Julia; Mayer, Moriz; Lips, Sebastian; Arnhof, Heribert; Scharn, Dirk; Haaksma, Eric E.J.; Leurs, Rob
European Journal of Medicinal Chemistry, 2012 , vol. 54, p. 660 - 668
反应条件
copper(l) iodide in dimethyl sulfoxide T=60°C; 0.166667 h; Ionic liquidInert atmosphereMicrowave irradiationSealed tube;
参考文献
Gu, Lijun; Li, Xiangguang
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 11 p. 2036 - 2039
反应条件
copper(l) iodide T=50°C; 0.166667 h; Ionic liquidInert atmosphereMicrowave irradiationSealed tube;
参考文献
Gu, Lijun; Li, Xiangguang
Journal of the Brazilian Chemical Society, 2011 , vol. 22, # 11 p. 2036 - 2039
反应条件
1.1: sodium ethanolate / tetrahydrofuran / 10 - 20 °C / Large scale reaction 1.2: 2 h / 20 °C 2.1: palladium 10 on activated carbon; ammonium formate; acetic acid / ethanol; water / 3.25 h / 35 °C / Large scale reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 15, # 5 p. 1040 - 1045
反应条件
1.1: pivalic acid sodium salt / 1-methyl-pyrrolidin-2-one / 2.75 h / 20 - 50 °C / Large scale reaction 2.1: sulfuric acid; water / 50 - 100 °C / Large scale reaction 3.1: sodium ethanolate / tetrahydrofuran / 10 - 20 °C / Large scale reaction 3.2: 2 h / 20 °C 4.1: palladium 10 on activated carbon; ammonium formate; acetic acid / ethanol; water / 3.25 h / 35 °C / Large scale reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 15, # 5 p. 1040 - 1045
反应条件
1.1: sulfuric acid; water / 50 - 100 °C / Large scale reaction 2.1: sodium ethanolate / tetrahydrofuran / 10 - 20 °C / Large scale reaction 2.2: 2 h / 20 °C 3.1: palladium 10 on activated carbon; ammonium formate; acetic acid / ethanol; water / 3.25 h / 35 °C / Large scale reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 15, # 5 p. 1040 - 1045
反应条件
1: pyridine; PPTS; Si(OEt)4 / 48 h / 20 °C 2: 343 mg / Cy2NH; pyridine / Pd(PPh3)4 / 0.33 h / 160 °C / microwave irradiation View Scheme
参考文献
Synthesis, , # 15 art. no. M01205SS, p. 2571 - 2577
