5-甲氧基-4-氮杂吲哚合成路线 （共 14 条）
反应条件
hydrogen; palladium on activated charcoal in ethanol P=2327.17 Torr; 5 h; Ambient temperature;
参考文献
Mazeas, Daniel; Guillaumet, Gerald; Viaud, Marie-Claude
Heterocycles, 1999 , vol. 50, # 2 p. 1065 - 1080
反应条件
hydrogen; palladium 10 on activated carbon in ethanol; ethyl acetate P=3102.97 Torr; 6 h; Parr apparatus;
参考文献
Roche Palo Alto LLC
Patent: US2007/123535 A1, 2007 ;
Location in patent: Page/Page column 42 ;
反应条件
hydrogen; palladium on activated charcoal in ethanol T=20°C; P=2068.59 Torr; 4 h;
参考文献
Filla, Sandra A.; Mathes, Brian M.; Johnson, Kirk W.; Phebus, Lee A.; Cohen, Marlene L.; Nelson, David L.; Zgombick, John M.; Erickson, Jon A.; Schenck, Kathryn W.; Wainscott, David B.; Branchek, Theresa A.; Schaus, John M.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 14 p. 3060 - 3071
反应条件
hydrogen; palladium on activated charcoal in ethanol
参考文献
Papageorgiou, Christos; Camenisch, Gian; Borer, Xaver
Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 12 p. 1549 - 1552
反应条件
1: 94 percent / potassium tert-butoxide / tetrahydrofuran / 3.5 h / -10 °C 2: 71 percent / hydrogen / palladium on charcoal / ethanol / 5 h / 20 °C / 2327.17 Torr View Scheme
参考文献
European Journal of Medicinal Chemistry, , vol. 39, # 6 p. 515 - 526
反应条件
1: Et3N / dimethylformamide / 2 h / 120 °C 2: 19.6 g / H2 / 10 percent Pd/C / ethanol / 4 h / 20 °C / 2068.59 Torr View Scheme
参考文献
Journal of Medicinal Chemistry, , vol. 46, # 14 p. 3060 - 3071
反应条件
1: 6-methoxy-3-nitro-2-picoline With hydrogen 2: tert-butoxy-bis-(dimethylamino)methane Heating / reflux;
参考文献
WO2005/9958 A1, ;
Page 176 ;
WO 2005/009958 A1
反应条件
hydrogen; palladium on activated charcoal 1.) reflux, 3 h, 2.) toluene; Yield given. Multistep reaction;
参考文献
Journal of medicinal chemistry, , vol. 38, # 13 p. 2331 - 2338
反应条件
potassium hydroxide in methanol
参考文献
Eli Lilly and Company
Patent: US6358972 B1, 2002 ;
US 6358972 B1
反应条件
1: 1.) phosphorus oxychloride, 2.) conc. HCl / 1.) 0 deg C, 1 h, 2.) MeOH, THF, RT, 45 min 2: 94 percent / HBr / acetic acid / 2 h / 100 °C View Scheme
参考文献
Buchheit; Gamse; Giger; Hoyer; Klein; Kloeppner; Pfannkuche; Mattes
Journal of medicinal chemistry, 1995 , vol. 38, # 13 p. 2331 - 2338
