1: 99.1 percent / Et3N / CH2Cl2 / 0.08 h / 0 °C 2: K2CO3 / methanol / 0.17 h / Ambient temperature 3: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 4: 69 percent / H2 / 10percent Pd/C / ethanol; CHCl3 / 6 h / 2280 Torr / Ambient temperature View Scheme

1: 99.1 percent / Et3N / CH2Cl2 / 0.08 h / 0 °C 2: K2CO3 / methanol / 0.17 h / Ambient temperature 3: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 4: 69 percent / H2 / 10percent Pd/C / ethanol; CHCl3 / 6 h / 2280 Torr / Ambient temperature View Scheme

1: 99.1 percent / Et3N / CH2Cl2 / 0.08 h / 0 °C 2: K2CO3 / methanol / 0.17 h / Ambient temperature 3: NaH / tetrahydrofuran / 0.5 h / Ambient temperature 4: 69 percent / H2 / 10percent Pd/C / ethanol; CHCl3 / 6 h / 2280 Torr / Ambient temperature View Scheme

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1209320', constants.ctx, '0')">sodium azide</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '4371014', constants.ctx, '0')">ammonium chloride</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587155', constants.ctx, '0')">water</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '605365', constants.ctx, '0')">N,N-dimethyl-formamide</a> <br />T=80&deg;C;&nbsp;2&nbsp;h;&nbsp;<br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 44.6 percent / 0.1M aq. phosphate buffer / acetone / lipase PS<br />2: 39.9 percent / NaHCO₃, mCPBA / CH₂Cl₂ / 24 h / Ambient temperature<br />3: 97.7 percent / NaN₃, NH₄Cl / dimethylformamide; H₂O / 2 h / 80 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: 39.9 percent / NaHCO₃, mCPBA / CH₂Cl₂ / 24 h / Ambient temperature<br />2: 97.7 percent / NaN₃, NH₄Cl / dimethylformamide; H₂O / 2 h / 80 &deg;C<br /> <br /> &nbsp;