3-甲酰基-5-硝基苯甲酸甲酯合成路线 （共 3 条）
反应条件
pyridine; hydrogenchloride; lithium tri(t-butoxy)aluminum hydride in tetrahydrofuran; N-methyl-acetamide; hexane; dichloromethane; ethyl acetate; acetonitrile
参考文献
BioCryst Pharmaceuticals, Inc.
Patent: US5602277 A1, 1997 ;
反应条件
copper(l) iodide; lithium tri-t-butoxyaluminum hydride in tetrahydrofuran; acetonitrile T=-78°C; 0.166667 h; Yield given. Yields of byproduct given;
参考文献
Chand, Pooran; Babu, Yarlagadda S.; Bantia, Shanta; Chu, Naiming; Cole, L. Brent; Kotian, Pravin L.; Laver, W. Graeme; Montgomery, John A.; Pathak, Ved P.; Petty, Sandra L.; Shrout, David P.; Walsh, David A.; Walsh, Gerald M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 25 p. 4030 - 4052
反应条件
1: 70 percent / BH3*THF / tetrahydrofuran / -10 - 64 °C 2: 78 percent / (COCl)2; DMSO; Et3N / CH2Cl2 / 0.75 h / -78 °C View Scheme
参考文献
Chand, Pooran; Babu, Yarlagadda S.; Bantia, Shanta; Chu, Naiming; Cole, L. Brent; Kotian, Pravin L.; Laver, W. Graeme; Montgomery, John A.; Pathak, Ved P.; Petty, Sandra L.; Shrout, David P.; Walsh, David A.; Walsh, Gerald M.
Journal of Medicinal Chemistry, 1997 , vol. 40, # 25 p. 4030 - 4052
