10,11-二氢-5H-二苯并[A,D]环庚烯-5-甲腈合成路线 （共 9 条）
反应条件
in acetonitrile; benzene T=20°C; 2 h; Heating / reflux;
参考文献
ALANTOS PHARMACEUTICALS, INC.
Patent: WO2006/116157 A2, 2006 ;
Location in patent: Page/Page column 62 ;
WO 2006/116157 A2
反应条件
tin(IV) chloride in dichloromethane 10 h; Ambient temperature;
参考文献
Valenta, Vladimir; Hulinska, Hana; Holubek, Jiri; Dlabac, Antonin; Metys, Jan; et al.
Collection of Czechoslovak Chemical Communications, 1988 , vol. 53, # 4 p. 860 - 869
反应条件
1: NH2OH*HCl, Py / ethanol 2: Ac2O View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 47, p. 4327 - 4333
反应条件
1: BF3-Et2O / CH2Cl2 2: NH2OH*HCl, Py / ethanol 3: Ac2O View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 47, p. 4327 - 4333
反应条件
thionyl chloride 1.) CH2Cl2, RT, 17 h, 2.) CH2Cl2, toluen, reflux, 2 h; Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 37, # 6 p. 804 - 810
反应条件
acetonitrile 1 h; Irradiation; Mechanism;
参考文献
Wan, Peter; Krogh, Erik
Journal of the American Chemical Society, 1989 , vol. 111, # 13 p. 4887 - 4895
参考文献
Canadian Journal of Chemistry, , vol. 47, p. 4327 - 4333
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 84, p. 1466 - 1477
参考文献
Davis,M.A. et al.
Journal of Medicinal Chemistry, 1964 , vol. 7, p. 88 - 94
