(R)-2-[3-(3-甲氧基丙氧基)-4-甲氧基苄基]-3-甲基丁-1-醇合成路线 （共 46 条）
反应条件
1: With lithium aluminium tetrahydride in tetrahydrofuran T=40°C; 2 h; Inert atmosphere; 2: With water; sodium hydroxide in tetrahydrofuran T=20°C;
参考文献
WO2011/151442 A2, ;
Page/Page column 21-22 ;
反应条件
1: With lithium borohydride in tetrahydrofuran; diethyl ether T=0°C; 0.666667 h; 2: With sodium hydroxide; water in tetrahydrofuran; diethyl ether T=0°C;
参考文献
WO2006/83924 A1, ;
Page/Page column 73; 75-76 ;
WO 2006/083924 A1
反应条件
1: With sodium tetrahydroborate in tetrahydrofuran T=0 - 15°C; 2: With boron trifluoride diethyl etherate in tetrahydrofuran T=60 - 65°C; 11 h;
参考文献
WO2011/148392 A1, ;
Page/Page column 61-62 ;
反应条件
hydrogen in ethanol T=25°C; P=37503.8 Torr; 16 h; Product distribution / selectivity;
参考文献
WO2008/77917 A1, ;
Page/Page column 57-59; 61 ;
反应条件
hydrogen; sodium t-butanolate; (S)-2-[(Sp)-2-(diphenylphosphino)ferrocenyl]-4-isopropyl-2-oxazoline triphenylphosphine ruthenium(II) chloride complex in isopropyl alcohol T=25°C; P=15001.5 Torr; 13 h; Product distribution / selectivity;
参考文献
WO2009/7462 A1, ;
Page/Page column 16 ;
反应条件
sodium tetrahydroborate in methanol T=0 - 20°C; 2 h;
参考文献
Green Chemistry, , vol. 12, # 10 p. 1747 - 1757
反应条件
n-butyllithium; borane-ammonia complex in tetrahydrofuran T=20°C;
参考文献
Tetrahedron Letters, , vol. 41, # 51 p. 10091 - 10094
反应条件
D-glucose; NADP; glucose dehydrogenase; DL-threo-1,4-dimercapto-2,3-butanediol in water T=25°C; pH=7.5; 24 h; Enzymatic reactionAqueous phosphate buffer; Product distribution / selectivity;
参考文献
WO2009/7462 A1, ;
Page/Page column 17-18 ;
反应条件
1: NaBH4 / ethanol 2: PBr3 / CH2Cl2 3: 76 percent / LiHMDS / tetrahydrofuran 4: 81 percent / LiOH; H2O2 5: 95 percent / LAH / tetrahydrofuran View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
sodium hydroxide; sodium borohydride; iodine in tetrahydrofuran; hydrogenchloride; methanol; water
参考文献
US5559111 A1, ;
US 5559111 A
