(R)-2-[3-(3-甲氧基丙氧基)-4-甲氧基苄基]-3-甲基丁-1-醇合成路线 （共 46 条）
反应条件
1.1: LDA; LiCl / tetrahydrofuran / 0 °C 1.2: tetrahydrofuran / 20 °C / Heating 2.1: 66 percent / BH3*NH3; n-BuLi / tetrahydrofuran / 20 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 41, # 51 p. 10091 - 10094
反应条件
1.1: hydrogenchloride; tri-(hydroxymethyl)-methylamine; water; HLAP / 48 h / 40 °C / Enzymatic reaction 1.2: 20 °C / pH 3.5 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere 2.2: 20 °C View Scheme
反应条件
1.1: hydrogenchloride; tri-(hydroxymethyl)-methylamine; water; HLAP / 48 h / 40 °C / Enzymatic reaction 1.2: 20 °C / pH 3.5 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere 2.2: 20 °C View Scheme
反应条件
1.1: hydrogenchloride; tri-(hydroxymethyl)-methylamine; water; HLAP / 48 h / 40 °C / Enzymatic reaction 1.2: 20 °C / pH 3.5 2.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere 2.2: 20 °C View Scheme
反应条件
1.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran; hexane / 1 h / |Cooling with ice; |Inert atmosphere 1.2: 16 h / -30 - -5 °C 2.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C View Scheme
反应条件
1.1: 4-(N,N-dimethlyamino)pyridine; triethylamine / toluene / 0 - 25 °C 2.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran; hexane / 1 h / |Cooling with ice; |Inert atmosphere 2.2: 16 h / -30 - -5 °C 3.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C View Scheme
反应条件
1.1: sodium iodide / tetrahydrofuran / 16 h / 25 - 30 °C 2.1: 1,1,1,3,3,3-hexamethyl-disilazane; n-butyllithium / tetrahydrofuran; hexane / 1 h / |Cooling with ice; |Inert atmosphere 2.2: 16 h / -30 - -5 °C 3.1: sodium tetrahydroborate / tetrahydrofuran; water / 20 °C View Scheme
反应条件
1.1: 72 percent / NaOMe / methanol / 1.5 h / Heating 2.1: 96 percent / NaBH4 / methanol / 1 h / 20 °C 3.1: 100 percent / Me3SiBr / 0.17 h / 20 °C 4.1: LiHMDS / tetrahydrofuran / 1.25 h / -70 °C 4.2: 86 percent / tetrahydrofuran / 18 h / 0 °C 5.1: 94 percent / H2O2; LiOH / tetrahydrofuran; H2O / 3 h / 20 °C 6.1: NaBH4 / tetrahydrofuran / 0.75 h / 20 °C 6.2: 90 percent / I2 / tetrahydrofuran / 96 h / 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 8 p. 2848 - 2870
反应条件
1.1: potassium carbonate / acetonitrile / 10 h / 25 - 35 °C / Reflux 2.1: phosphorus tribromide / dichloromethane / 2 h / 0 - 10 °C 3.1: toluene / 2 h / 85 - 90 °C 4.1: sodium hydroxide; water / ethanol / 72 h / Reflux 4.2: pH 1 - 1.2 4.3: 35 h / 155 °C 5.1: (S)-1-phenyl-ethylamine / ethyl acetate / 4 h / 10 °C 5.2: pH 1 - 1.2 6.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 20 °C 6.2: 5 °C View Scheme
反应条件
1.1: (S)-1-phenyl-ethylamine / ethyl acetate / 4 h / 10 °C 1.2: pH 1 - 1.2 2.1: sodium bis(2-methoxyethoxy)aluminium dihydride / toluene / 2 h / 20 °C 2.2: 5 °C View Scheme
