(R)-2-[3-(3-甲氧基丙氧基)-4-甲氧基苄基]-3-甲基丁-1-醇合成路线 (共 46 条)
反应条件
1: 97 percent / PPh3; NBS / CH2Cl2
2: 68 percent / n-BuLi
3: HCl / acetonitrile
4: Et3N
5: NaBH4 / ethanol
View Scheme
参考文献
Goeschke, Richard; Stutz, Stefan; Heinzelmann, Walter; Maibaum, Juergen
Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2848 - 2870
反应条件
1: 97 percent / PPh3; NBS / CH2Cl2
2: 68 percent / n-BuLi
3: HCl / acetonitrile
4: Et3N
5: NaBH4 / ethanol
6: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2
7: Mg
8: 23 percent / H2 / Pd(OH)2/C
9: 38 percent / TPAP; NMMO
10: 65 percent / 2-hydroxypyridine; Et3N
View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
Jone's reagent in acetone
T=0°C; 1 h;
参考文献
Rosini, Goffredo; Paolucci, Claudio; Boschi, Francesca; Marotta, Emanuela; Righi, Paolo; Tozzi, Francesco
Green Chemistry, 2010 , vol. 12, # 10 p. 1747 - 1757
反应条件
1: 97 percent / PPh3; NBS / CH2Cl2
2: 68 percent / n-BuLi
3: HCl / acetonitrile
4: Et3N
5: NaBH4 / ethanol
6: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2
7: Mg
8: 23 percent / H2 / Pd(OH)2/C
9: 38 percent / TPAP; NMMO
View Scheme
参考文献
CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo
Patent: WO2011/151442 A2, 2011 ;
反应条件
1.1: 97 percent / NBS; Ph3P / CH2Cl2 / 18 h / 20 °C
2.1: BuLi / hexane / 0.5 h / -75 °C
2.2: 91 percent / tetrahydrofuran / 20 h / -75 - -20 °C
3.1: 90 percent / 1N HCl / acetonitrile / 1.5 h / 20 °C
4.1: 82 percent / Et3N / CH2Cl2 / 20 h / 20 °C
View Scheme
参考文献
Goeschke, Richard; Stutz, Stefan; Heinzelmann, Walter; Maibaum, Juergen
Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2848 - 2870
反应条件
1H-imidazole; iodine; triphenylphosphine in dichloromethane
3 h;
参考文献
VITAE PHARMACEUTICALS, INC.
Patent: WO2007/123718 A1, 2007 ;
Location in patent: Example 1 ;
WO 2007/123718 A1