(ar)-4-甲氧基-3-(3-甲氧基丙氧基)-a-(1-甲基乙基)-苯丙酸合成路线 （共 48 条）
反应条件
sodium hydroxide; sodium borohydride; iodine in tetrahydrofuran; hydrogenchloride; methanol; water
参考文献
US5559111 A1, ;
US 5559111 A
反应条件
bis(1,5-cyclooctadiene)-rhodium(I) tetrafluoroborate; C23H20NO2P; hydrogen; triphenylphosphine in water; isopropyl alcohol
T=55°C; P=60006 Torr; 18 h; Autoclave; Reagent/catalystSolventPressureTemperature;
参考文献
Boogers, Jeroen A. F.; Felfer, Ulfried; Kotthaus, Martina; Lefort, Laurent; Steinbauer, Gerhard; De Vries, Andre H. M.; De Vries, Johannes G.
Organic Process Research and Development, 2007 , vol. 11, # 3 p. 585 - 591
反应条件
hydrogen in methanol
T=20°C; P=37503.8 Torr;
参考文献
Sturm, Thomas; Weissensteiner, Walter; Spindler, Felix
Advanced Synthesis and Catalysis, 2003 , vol. 345, # 1-2 p. 160 - 164
反应条件
dihydrogen peroxide; lithium hydroxide hydrate in tetrahydrofuran; water
T=0 - 20°C;
参考文献
Rosini, Goffredo; Paolucci, Claudio; Boschi, Francesca; Marotta, Emanuela; Righi, Paolo; Tozzi, Francesco
Green Chemistry, 2010 , vol. 12, # 10 p. 1747 - 1757
反应条件
1: With hydrogenchloride; HLAP; water; tri-(hydroxymethyl)-methylamine
T=40°C; 48 h; Enzymatic reaction;
2: With citric acid in water
T=20°C; pH=3.5;
参考文献
CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo
Patent: WO2011/151442 A2, 2011 ;
Location in patent: Page/Page column 20-21 ;
反应条件
1: With hydrogenchloride; HLAP; water; tri-(hydroxymethyl)-methylamine
T=40°C; 48 h; Enzymatic reaction;
2: With citric acid in water
T=20°C; pH=3.5;
参考文献
CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo
Patent: WO2011/151442 A2, 2011 ;
Location in patent: Page/Page column 20-21 ;
反应条件
1: With (S)-1-phenyl-ethylamine in ethyl acetate
T=10°C; 4 h;
2: With hydrogenchloride in water
pH=1 - 1.2;
参考文献
WATSON LABORATORIES, INC.; BHANU, Manjunath, Narayan; NAIK, Samir; THOMAS, Rejoy
Patent: WO2012/78147 A1, 2012 ;
Location in patent: Page/Page column 18-19 ;
反应条件
1: With hydrogenchloride; HLAP; water; tri-(hydroxymethyl)-methylamine
T=40°C; 48 h; Enzymatic reaction;
2: With citric acid in water
T=20°C; pH=3.5;
参考文献
CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo
Patent: WO2011/151442 A2, 2011 ;
Location in patent: Page/Page column 20-21 ;
反应条件
HLAP; water in aq. buffer
T=40°C; pH=7.5; 48 h; Enzymatic reaction;
参考文献
Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo
Patent: US2013/71899 A1, 2013 ;
Location in patent: Paragraph 0095-0107 ;
反应条件
HLAP; water in aq. buffer
T=40°C; pH=7.5; 48 h; Enzymatic reaction;
参考文献
Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo
Patent: US2013/71899 A1, 2013 ;
Location in patent: Paragraph 0095-0107 ;
