(ar)-4-甲氧基-3-(3-甲氧基丙氧基)-a-(1-甲基乙基)-苯丙酸合成路线 （共 48 条）
反应条件
1.1: lithium diisopropyl amide / tetrahydrofuran; n-heptane; ethylbenzene / 1 h / -40 °C / |Inert atmosphere
1.2: 2.25 h / -40 °C
2.1: camphor-10-sulfonic acid / toluene / |Reflux; |Dean-Stark
3.1: hydrogen; palladium 10 on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr
4.1: HLAP; water / aq. buffer / 48 h / 40 °C / pH 7.5 / |Enzymatic reaction
View Scheme
参考文献
Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo
Patent: US2013/71899 A1, 2013 ;
反应条件
1: camphor-10-sulfonic acid / toluene / |Reflux; |Dean-Stark
2: hydrogen; palladium 10 on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr
3: HLAP; water / aq. buffer / 48 h / 40 °C / pH 7.5 / |Enzymatic reaction
View Scheme
参考文献
Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo
Patent: US2013/71899 A1, 2013 ;
反应条件
1: hydrogen; palladium 10 on activated carbon / methanol / 18 h / 20 °C / 760.05 Torr
2: HLAP; water / aq. buffer / 48 h / 40 °C / pH 7.5 / |Enzymatic reaction
View Scheme
参考文献
Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo
Patent: US2013/71899 A1, 2013 ;
反应条件
1: 95 percent / LAH / tetrahydrofuran
2: 97 percent / PPh3; NBS / CH2Cl2
3: 68 percent / n-BuLi
4: HCl / acetonitrile
5: Et3N
6: NaBH4 / ethanol
View Scheme
参考文献
Goeschke, Richard; Stutz, Stefan; Heinzelmann, Walter; Maibaum, Juergen
Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2848 - 2870
反应条件
1: 95 percent / LAH / tetrahydrofuran
2: 97 percent / PPh3; NBS / CH2Cl2
3: 68 percent / n-BuLi
4: HCl / acetonitrile
5: Et3N
6: NaBH4 / ethanol
7: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2
8: Mg
9: 23 percent / H2 / Pd(OH)2/C
10: 38 percent / TPAP; NMMO
11: 65 percent / 2-hydroxypyridine; Et3N
View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 95 percent / LAH / tetrahydrofuran
2: 97 percent / PPh3; NBS / CH2Cl2
3: 68 percent / n-BuLi
4: HCl / acetonitrile
5: Et3N
6: NaBH4 / ethanol
7: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2
8: Mg
9: 23 percent / H2 / Pd(OH)2/C
10: 38 percent / TPAP; NMMO
View Scheme
参考文献
CHEMO IBERICA, S.A.; TADDEI, Maurizio; RUSSO, Adele; CINI, Elena; RIVA, Renata; RASPARINI, Marcello; CARCONE, Luca; BANFI, Luca; VITALE, Romina; ROSEBLADE, Stephen; ZANOTTI-GEROSA, Antonio Carlo
Patent: WO2011/151442 A2, 2011 ;
反应条件
1.1: NaBH4 / tetrahydrofuran / 0.75 h / 20 °C
1.2: 90 percent / I2 / tetrahydrofuran / 96 h / 20 °C
2.1: 97 percent / NBS; Ph3P / CH2Cl2 / 18 h / 20 °C
3.1: BuLi / hexane / 0.5 h / -75 °C
3.2: 91 percent / tetrahydrofuran / 20 h / -75 - -20 °C
4.1: 90 percent / 1N HCl / acetonitrile / 1.5 h / 20 °C
5.1: 82 percent / Et3N / CH2Cl2 / 20 h / 20 °C
View Scheme
参考文献
Goeschke, Richard; Stutz, Stefan; Heinzelmann, Walter; Maibaum, Juergen
Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2848 - 2870
反应条件
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 40 °C / Inert atmosphere
1.2: 20 °C
2.1: triethylamine / toluene / 1.5 h / 0 - 20 °C / Inert atmosphere
3.1: sodium iodide / acetonitrile / Inert atmosphere; Reflux
View Scheme
参考文献
Chemo Iberica, S.A.; Taddei, Maurizio; Russo, Adele; Cini, Elena; Riva, Renata; Rasparini, Marcello; Carcone, Luca; Banfi, Luca; Vitale, Romina; Roseblade, Stephen; Zanotti-Gerosa, Antonio Carlo
Patent: US2013/71899 A1, 2013 ;
