3-(3-甲氧基丙氧基)-4-甲氧基苄醇合成路线 （共 21 条）
反应条件
sodium tetrahydroborate in methanol T=20°C; 1 h;
参考文献
Goeschke, Richard; Stutz, Stefan; Heinzelmann, Walter; Maibaum, Juergen
Helvetica Chimica Acta, 2003 , vol. 86, # 8 p. 2848 - 2870
反应条件
potassium carbonate in water; acetone
参考文献
US5559111 A1, ;
US 5559111 A
反应条件
1: With potassium carbonate in toluene 10 h; Reflux; 2: With methanol; sodium tetrahydroborate T=0 - 30°C; 8 h;
参考文献
WO2011/148392 A1, ;
Page/Page column 59 ;
反应条件
1: 98 percent / K2CO3 / acetonitrile 2: NaBH4 / ethanol View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: 72 percent / NaOMe / methanol / 1.5 h / Heating 2: 96 percent / NaBH4 / methanol / 1 h / 20 °C View Scheme
参考文献
Helvetica Chimica Acta, , vol. 86, # 8 p. 2848 - 2870
反应条件
1.1: phosphorus tribromide / dichloromethane / 2.17 h / 0 - 5 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere 2.2: -70 - 5 °C 3.1: dihydrogen peroxide; lithium hydroxide hydrate / water; tetrahydrofuran / 0 - 30 °C 4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere 4.2: 5.75 h / 0 - 30 °C 5.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C View Scheme
参考文献
MYLAN LABORATORIES LTD; RAMA, Shankar; VADALI, Lakshmana Rao; GORANTLA, Sarat Chandra Srikanth; MANUKONDA, Seshadri rao; POTLA, Venkata Srinivas Rao; VADLAMUDI, Mohana Vamsi Krishna; POTHANI, Jayaram; ANUPATI, Raja Reddy
Patent: WO2013/118138 A1, 2013 ;
反应条件
1.1: phosphorus tribromide / dichloromethane / 2.17 h / 0 - 5 °C 2.1: lithium hexamethyldisilazane / tetrahydrofuran / 2 h / -70 °C / Inert atmosphere 2.2: -70 - 5 °C 3.1: dihydrogen peroxide; lithium hydroxide hydrate / water; tetrahydrofuran / 0 - 30 °C 4.1: sodium tetrahydroborate / tetrahydrofuran / 1 h / 0 - 5 °C / Inert atmosphere 4.2: 5.75 h / 0 - 30 °C 5.1: N-chloro-succinimide; triphenylphosphine / dichloromethane / 5.5 h / -40 - 30 °C 6.1: magnesium; ethylene dibromide / tetrahydrofuran / 4.17 h / 63 - 68 °C / Inert atmosphere 6.2: 1 h / 0 - 5 °C View Scheme
反应条件
1: PBr3 / CH2Cl2 2: 76 percent / LiHMDS / tetrahydrofuran 3: 81 percent / LiOH; H2O2 4: 95 percent / LAH / tetrahydrofuran 5: 97 percent / PPh3; NBS / CH2Cl2 6: 68 percent / n-BuLi 7: HCl / acetonitrile 8: Et3N 9: NaBH4 / ethanol 10: 89 percent / DMSO; ClC(O)C(O)Cl; Et3N / CH2Cl2 11: Mg 12: 23 percent / H2 / Pd(OH)2/C 13: 38 percent / TPAP; NMMO 14: 65 percent / 2-hydroxypyridine; Et3N 15: TMSCl; phenol / CH2Cl2 View Scheme
参考文献
Tetrahedron Letters, , vol. 46, # 37 p. 6337 - 6340
反应条件
1: PBr3 / CH2Cl2 2: 76 percent / LiHMDS / tetrahydrofuran 3: 81 percent / LiOH; H2O2 4: 95 percent / LAH / tetrahydrofuran 5: 97 percent / PPh3; NBS / CH2Cl2 6: 68 percent / n-BuLi View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
反应条件
1: PBr3 / CH2Cl2 2: 76 percent / LiHMDS / tetrahydrofuran 3: 81 percent / LiOH; H2O2 4: 95 percent / LAH / tetrahydrofuran 5: 97 percent / PPh3; NBS / CH2Cl2 6: 68 percent / n-BuLi 7: HCl / acetonitrile 8: Et3N 9: LiOH / methanol; H2O 10: EDCI; HOBt View Scheme
参考文献
Dong, Hua; Zhang, Zhi-Liu; Huang, Jia-Hui; Ma, Rujian; Chen, Shu-Hui; Li, Ge
Tetrahedron Letters, 2005 , vol. 46, # 37 p. 6337 - 6340
