methanol; potassium carbonate T=20°C; 24 h;

<b>Multi-step reaction with 2 steps<br /> </b>1: 81 percent / aq. K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 16 h / 90 &deg;C<br />2: 77 percent / pyridine / 16 h / 20 &deg;C<br /> <br /> &nbsp;

<b>Multi-step reaction with 3 steps<br /> </b>1: 81 percent / Br₂ / acetate buffer / 47 h / 20 &deg;C / pH 4<br />2: 81 percent / aq. K₂CO₃ / Pd(PPh₃)4 / 1,2-dimethoxy-ethane / 16 h / 90 &deg;C<br />3: 77 percent / pyridine / 16 h / 20 &deg;C<br /> <br /> &nbsp;