2-甲氧基-联苯-2-羧酸合成路线 （共 24 条）
参考文献
Merck and Co., Inc.
Patent: US4459422 A1, 1984 ;
反应条件
1: With palladium diacetate in water
T=20°C; Suzuki-Miyaura coupling; 0.0833333 h;
2: With potassium hydroxide in water
T=20 - 75°C; 5 h;
参考文献
Korolev, Dmitrii N.; Bumagin, Nikolay A.
Tetrahedron Letters, 2006 , vol. 47, # 25 p. 4225 - 4229
反应条件
1: 2-methoxy-phenylmagnesium bromide With titanium tetraethoxide in tetrahydrofuran
T=20°C; 0.5 h; Inert atmosphere;
2: 2-Bromobenzoic acid With tributylphosphine; cobalt(II) chloride in tetrahydrofuran
T=20°C; Inert atmosphere; chemoselective reaction;
参考文献
Zeng, Jing; Liu, Kun Ming; Duan, Xin Fang
Organic Letters, 2013 , vol. 15, # 20 p. 5342 - 5345
反应条件
1: With palladium diacetate in N,N-dimethyl-formamide
T=60°C; Addition; 3 h;
2: With hydrogenchloride in N,N-dimethyl-formamide
T=20°C; Hydrolysis;
参考文献
Xia, Min; Chen, Zhenchu
Synthetic Communications, 2000 , vol. 30, # 1 p. 63 - 68
反应条件
1: With palladium diacetate in N,N-dimethyl-formamide
T=60°C; Addition; 3 h;
2: With hydrogenchloride in N,N-dimethyl-formamide
T=20°C; Hydrolysis;
参考文献
Xia, Min; Chen, Zhenchu
Synthetic Communications, 2000 , vol. 30, # 1 p. 63 - 68
反应条件
sodium methylate in N,N,N',N',N'',N''-hexamethylphosphoric triamide; toluene
1.5 h; Heating;
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
1: 98 percent / diethyl ether; benzene / 1 h / Ambient temperature
2: 100 percent / NaOCH3 / hexamethylphosphoric acid triamide; toluene / 1.5 h / Heating
View Scheme
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
1: 73 percent / triluoroacetic anhydride / 4 h / Ambient temperature
2: 98 percent / diethyl ether; benzene / 1 h / Ambient temperature
3: 100 percent / NaOCH3 / hexamethylphosphoric acid triamide; toluene / 1.5 h / Heating
View Scheme
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
1: 98 percent / diethyl ether; benzene / 1 h / Ambient temperature
2: 100 percent / NaOCH3 / hexamethylphosphoric acid triamide; toluene / 1.5 h / Heating
View Scheme
参考文献
Hattori, Tetsutaro; Suzuki, Takatsugu; Hayashizaka, Noriyuki; Koike, Nobuyuki; Miyano, Sotaro
Bulletin of the Chemical Society of Japan, 1993 , vol. 66, # 10 p. 3034 - 3040
反应条件
1: 59 percent / tetrahydrofuran
2: 1) singlet oxygen, 2.) LiOH / 2.) heating
View Scheme
参考文献
Cram, Donald J.; Bryant, Judi A.; Doxsee, Kenneth M.
Chemistry Letters, 1987 , p. 19 - 22
