3-叔-丁基环己-2-烯-1-酮合成路线 （共 17 条）
反应条件
tert.-butylhydroperoxide; Rh2(Cap)4; potassium carbonate in dichloromethane
1 h;
参考文献
Catino, Arthur J.; Forslund, Raymond E.; Doyle, Michael P.
Journal of the American Chemical Society, 2004 , vol. 126, # 42 p. 13622 - 13623
反应条件
CuSPh in tetrahydrofuran; pentane
T=0°C; 2.5 h;
参考文献
Piers, Edward; Cheng, Kin Fai; Nagakura, Isao
Canadian Journal of Chemistry, 1982 , vol. 60, p. 1256 - 1263
反应条件
1: With copper(l) iodide in diethyl ether
T=-20°C; Grignard reaction; 1 h;
2: With Mukayama reagent in tetrahydrofuran; diethyl ether
T=-78 - 20°C; 16 h;
参考文献
Kerr, William J.; Pearson, Colin M.; Thurston, Graeme J.
Organic and Biomolecular Chemistry, 2006 , vol. 4, # 1 p. 47 - 50
反应条件
in tetrahydrofuran; pentane
T=-78°C; Inert atmosphere;
参考文献
Coote, Susannah C.; O'Brien, Peter; Whitwood, Adrian C.
Organic and Biomolecular Chemistry, 2008 , vol. 6, # 23 p. 4299 - 4314
反应条件
1: tert.-butyl lithium in diethyl ether
T=-78°C;
2: cyclohexenon in diethyl ether
T=-78°C;
3: With Mukayama reagent in diethyl ether
T=-78°C; 0.5 h;
参考文献
Matsuo, Jun-Ichi; Aizawa, Yayoi
Chemical Communications, 2005 , # 18 p. 2399 - 2401
反应条件
1: 1.) lithium diisopropylamide (LDA), 2.) HMPA, triethylamine / 1.) a) THF, -78 deg C, 1 h, b) from -78 deg C to 0 deg C, 5 min, 2.) -78 deg C, 1 h
2: 1.) methyllithium, 2) N-chlorosuccinimide / 1.) THF, RT, 1 h, 2.) -70 deg C, 1 h
3: 51 percent / lithium chloride / dimethylformamide / 23 h / 50 °C
View Scheme
参考文献
Denmark; Dappen; Sear; Jacobs
Journal of the American Chemical Society, 1990 , vol. 112, # 9 p. 3466 - 3474
反应条件
oxygen; [Bu4N]4W10O32 in acetonitrile
T=5 - 10°C; 0.25 h; Irradiation; Title compound not separated from byproducts;
参考文献
Lykakis, Ioannis N.; Orfanopoulos, Michael
Synlett, 2004 , # 12 p. 2131 - 2134
反应条件
diethyl ether
Eintragen des Reaktionsgemisches in wss. H2SO4 und anschliessennd Destillieren mit Wasser-Dampf;
参考文献
Woods et al.
Journal of the American Chemical Society, 1949 , vol. 71, p. 2028
反应条件
1: LiAlH4 / diethyl ether / 0.25 h / Heating
3: 63 percent / formic acid / 0.08 h / Heating
View Scheme
参考文献
Liotta, Dennis; Zima, George; Saindane, Manohar
Journal of Organic Chemistry, 1982 , vol. 47, # 7 p. 1258 - 1267
反应条件
1: 1.) TiCl4, Ti(i-PrO)4 / 1.) dichloromethane, -78 deg C, 30 min, 2.) dichloromethane, -50 deg C, 18 h
2: 74 percent / sodium hydride / tetrahydrofuran; hexamethylphosphoric acid triamide / 2 h / Heating
View Scheme
参考文献
Wada, Eiji; Funakoshi, Junji; Kanemasa, Shuji
Bulletin of the Chemical Society of Japan, 1992 , vol. 65, # 9 p. 2456 - 2464
